iPTMnet Report for P00374 (DHFR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00374 / DYR_HUMAN
Protein Name Dihydrofolate reductase
Gene Name Name: DHFR
Organism Homo sapiens (Human)

PRO ID PR:P00374
DAG View
PRO Name dihydrofolate reductase (human)
Definition A dihydrofolate reductase that is encoded in the genome of human.
Short Label hDHFR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00374 (DHFR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
R29 Methylation PhosphoSitePlus
R33 Methylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K81 Sumoylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
K99 Sumoylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
K156 Sumoylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
K158 Sumoylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
K174 Acetylation PhosphoSitePlus
K174 Sumoylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K179 Sumoylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R33 T33 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K55 R55 Biomuta DOID:263 / kidney cancer [ cosmic ]