iPTMnet Report for P00367 (GLUD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00367 / DHE3_HUMAN
Protein Name Glutamate dehydrogenase 1, mitochondrial precursor
Gene Name Name: GLUD1
Synonyms:GLUD;
Organism Homo sapiens (Human)

PRO ID PR:P00367
DAG View
PRO Name glutamate dehydrogenase 1, mitochondrial (human)
Definition A glutamate dehydrogenase 1, mitochondrial that is encoded in the genome of human.
Short Label hGLUD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00367 (GLUD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K68 Acetylation PhosphoSitePlus
R76 Methylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
K84 Acetylation PhosphoSitePlus   UniProt 19608861
K84 Ubiquitination PhosphoSitePlus
K98 Acetylation PhosphoSitePlus
C112 S-Nitrosylation dbSNO 24105792
S128 Phosphorylation PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
K162 Acetylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
Y170 Phosphorylation PhosphoSitePlus
K171 Methylation PhosphoSitePlus
K183 Sumoylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
T206 Phosphorylation PhosphoSitePlus
K211 Acetylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus   UniProt 24275569
T228 Phosphorylation PhosphoSitePlus
K302 Methylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
K346 Acetylation PhosphoSitePlus
K352 Acetylation PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
Y367 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus   UniProt 24275569
K386 Ubiquitination PhosphoSitePlus
K390 Acetylation PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
T409 Phosphorylation PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
K415 Acetylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
Y439 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus
K457 Acetylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
Y464 Phosphorylation PhosphoSitePlus
K480 Acetylation PhosphoSitePlus   UniProt 19608861
K480 Ubiquitination PhosphoSitePlus
R496 Methylation PhosphoSitePlus
K503 Acetylation PhosphoSitePlus   UniProt 19608861
K503 Ubiquitination PhosphoSitePlus
Y512 Phosphorylation PhosphoSitePlus   UniProt 24275569
T513 Phosphorylation PhosphoSitePlus
K527 Acetylation PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
Y528 Phosphorylation PhosphoSitePlus
Y539 Phosphorylation PhosphoSitePlus
K545 Acetylation PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
Y550 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S79 Phosphorylation HPRD 20166139
S128 Phosphorylation HPRD 20166139
T410 Phosphorylation HPRD 19413330
S450 Phosphorylation HPRD 20166139


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S157 N157 Biomuta [ cosmic ]
K200 N200 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S227 N227 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S227 I227 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S316 C316 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K352 I352 Biomuta DOID:4159 / skin cancer [ cosmic ]
S357 F357 Biomuta DOID:4159 / skin cancer [ cosmic ]
K399 R399 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y439 H439 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S462 Y462 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R496 G496 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K527 T527 Biomuta DOID:9256 / colorectal cancer [ cosmic ]