iPTMnet Report for P00352 (ALDH1A1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00352 / AL1A1_HUMAN
Protein Name Aldehyde dehydrogenase 1A1
Gene Name Name: ALDH1A1
Synonyms:ALDC,ALDH1;
Organism Homo sapiens (Human)

PRO ID PR:P00352
DAG View
PRO Name aldehyde dehydrogenase 1A1 (human)
Definition An aldehyde dehydrogenase 1A1 that is encoded in the genome of human.
Short Label hALDH1A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00352 (ALDH1A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22223895, 6723659
S2 Phosphorylation HPRD 20068231
T6 Phosphorylation PhosphoSitePlus
K22 Acetylation PhosphoSitePlus
K37 Acetylation PhosphoSitePlus
K65 Acetylation PhosphoSitePlus
R68 Methylation PhosphoSitePlus
R85 Methylation PhosphoSitePlus
K91 Acetylation PhosphoSitePlus   UniProt 19608861
T105 Phosphorylation PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus   UniProt 19608861
K128 Ubiquitination PhosphoSitePlus
C133 Methylation IEDB 31844290
K139 Acetylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
Y154 Phosphorylation PhosphoSitePlus
K252 Acetylation PhosphoSitePlus   UniProt 19608861
T267 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 20166139, 28193222
S314 Phosphorylation PhosphoSitePlus
Y316 Phosphorylation PhosphoSitePlus
K329 Acetylation PhosphoSitePlus
T337 Phosphorylation PhosphoSitePlus   UniProt 24275569
T341 Phosphorylation PhosphoSitePlus
K353 Acetylation PhosphoSitePlus   UniProt 19608861
S360 Phosphorylation HPRD   PhosphoSitePlus 20068231
K362 Acetylation PhosphoSitePlus
K367 Acetylation PhosphoSitePlus   UniProt 19608861
Y380 Phosphorylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
K410 Acetylation PhosphoSitePlus   UniProt 19608861
K412 Acetylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus   UniProt 24275569
K419 Acetylation PhosphoSitePlus   UniProt 19608861
T424 Phosphorylation PhosphoSitePlus
Y426 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
K435 Acetylation PhosphoSitePlus   UniProt 19608861
K435 Ubiquitination PhosphoSitePlus
T442 Phosphorylation PhosphoSitePlus   RLIMS-P 28193222
K470 Acetylation PhosphoSitePlus
Y481 Phosphorylation PhosphoSitePlus
Y486 Phosphorylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
T493 Phosphorylation PhosphoSitePlus   RLIMS-P 28193222
K495 Acetylation PhosphoSitePlus   UniProt 19608861
K495 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T6 M6 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K22 E22 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T144 A144 Biomuta DOID:4159 / skin cancer [ cosmic ]
K252 R252 Biomuta DOID:3571 / liver cancer [ cosmic ]
K410 N410 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S413 C413 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]