Protein Information

Cytoscape View

UniProt AC / UniProt ID P00338 / LDHA_HUMAN
Protein Name L-lactate dehydrogenase A chain
Gene Name Name: LDHA
Organism Homo sapiens (Human)

PRO ID PR:P00338
DAG View
PRO Name L-lactate dehydrogenase A chain (human)
Definition An L-lactate dehydrogenase A chain that is encoded in the genome of human.
Short Label hLDHA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P00338 (LDHA) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
T3 Phosphorylation PhosphoSitePlus
K5 Acetylation PhosphoSitePlus   UniProt 19608861
K5 Methylation PhosphoSitePlus
K5 Ubiquitination PhosphoSitePlus
Y10 Phosphorylation P04626 (ERBB2) , P12931 (SRC) , P11362 (FGFR1) PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 28516914, 30745841, 28218905, ...21969607, 19690332
K14 Acetylation PhosphoSitePlus   UniProt 19608861
K14 Sumoylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
T18 Phosphorylation PhosphoSitePlus   UniProt 23186163
K22 Acetylation PhosphoSitePlus
K57 Acetylation PhosphoSitePlus   UniProt 19608861
K57 Ubiquitination PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
T74 Phosphorylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K81 Acetylation PhosphoSitePlus   UniProt 19608861
K81 Ubiquitination PhosphoSitePlus
Y83 Phosphorylation P11362 (FGFR1) PhosphoSitePlus   RLIMS-P   Signor 21969607
S89 Phosphorylation PhosphoSitePlus
K90 Acetylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
K118 Acetylation PhosphoSitePlus   UniProt 19608861
K118 Methylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K126 Acetylation PhosphoSitePlus   UniProt 19608861
K126 Ubiquitination PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
K132 Acetylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
Y145 Phosphorylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
R157 Methylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
R169 Methylation PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K222 Acetylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K224 Acetylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K228 Acetylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K232 Acetylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
Y239 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455, 18083107
K243 Acetylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
T248 Phosphorylation P06493 (CDK1) PhosphoSitePlus 18234856
S249 Phosphorylation PhosphoSitePlus
R269 Methylation PhosphoSitePlus
K278 Acetylation PhosphoSitePlus
K278 Methylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
T309 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K317 Ubiquitination PhosphoSitePlus
K318 Acetylation PhosphoSitePlus   UniProt 19608861
K318 Ubiquitination PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
T322 Phosphorylation PhosphoSitePlus
K328 Acetylation PhosphoSitePlus
K328 Sumoylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y10 Phosphorylation HPRD 20068231
Y239 Phosphorylation HPRD 15592455, 16497976
Site PTM Type PTM Enzyme Score Source PMID
Y232 Phosphorylation PhosphoSitePlus
T233 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K27 Ubiquitination PhosphoSitePlus

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P00338 (LDHA) Y10 Q16589 (CCNG2) unknown eFIP 30745841

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 G2 Biomuta DOID:363 / uterine cancer [ tcga ]
K22 N22 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T74 S74 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
K81 R81 Biomuta DOID:10534 / stomach cancer [ tcga ]
R157 C157 Biomuta DOID:10534 / stomach cancer [ tcga ]
R269 W269 Biomuta DOID:363 / uterine cancer [ tcga ]
K278 N278 Biomuta DOID:1324 / lung cancer [ cosmic ]
S310 P310 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]