iPTMnet Report for P00338 (LDHA)
Protein Information
UniProt AC / UniProt ID | P00338 / LDHA_HUMAN |
Protein Name | L-lactate dehydrogenase A chain |
Gene Name | Name: LDHA ORFNames:PIG19; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P00338 |
PRO Name | L-lactate dehydrogenase A chain (human) |
Definition | An L-lactate dehydrogenase A chain that is encoded in the genome of human. |
Short Label | hLDHA |
Category | organism-gene |
P00338 (LDHA) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 19413330, 22223895 | ||
T3 | Phosphorylation | score1 | PhosphoSitePlus | |||
K5 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K5 | Methylation | score1 | PhosphoSitePlus | |||
K5 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y10 | Phosphorylation | P04626 (ERBB2) , P12931 (SRC) , P11362 (FGFR1) | score4 | PhosphoSitePlus RLIMS-P+ RLIMS-P Signor UniProt | 28516914, 30745841, 28218905, ... | |
K14 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K14 | Sumoylation | score1 | PhosphoSitePlus | |||
K14 | Ubiquitination | score1 | PhosphoSitePlus | |||
T18 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K22 | Acetylation | score1 | PhosphoSitePlus | |||
K57 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K57 | Ubiquitination | score1 | PhosphoSitePlus | |||
K59 | Ubiquitination | score1 | PhosphoSitePlus | |||
T74 | Phosphorylation | score1 | PhosphoSitePlus | |||
K76 | Ubiquitination | score1 | PhosphoSitePlus | |||
K81 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K81 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y83 | Phosphorylation | P11362 (FGFR1) | score3 | PhosphoSitePlus RLIMS-P Signor | 21969607 | |
S89 | Phosphorylation | score1 | PhosphoSitePlus | |||
K90 | Acetylation | score1 | PhosphoSitePlus | |||
K90 | Ubiquitination | score1 | PhosphoSitePlus | |||
T95 | Phosphorylation | score1 | PhosphoSitePlus | |||
K118 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K118 | Methylation | score1 | PhosphoSitePlus | |||
K118 | Ubiquitination | score1 | PhosphoSitePlus | |||
K126 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K126 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y127 | Phosphorylation | score1 | PhosphoSitePlus | |||
S128 | Phosphorylation | score1 | PhosphoSitePlus | |||
K132 | Acetylation | score1 | PhosphoSitePlus | |||
K132 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y145 | Phosphorylation | score1 | PhosphoSitePlus | |||
K155 | Ubiquitination | score1 | PhosphoSitePlus | |||
R157 | Methylation | score1 | PhosphoSitePlus | |||
S161 | Phosphorylation | score1 | PhosphoSitePlus | |||
S167 | Phosphorylation | score1 | PhosphoSitePlus | |||
R169 | Methylation | score1 | PhosphoSitePlus | |||
Y172 | Phosphorylation | score1 | PhosphoSitePlus | |||
S184 | Phosphorylation | score1 | PhosphoSitePlus | |||
K212 | Ubiquitination | score1 | PhosphoSitePlus | |||
K222 | Acetylation | score1 | PhosphoSitePlus | |||
K222 | Ubiquitination | score1 | PhosphoSitePlus | |||
K224 | Acetylation | score1 | PhosphoSitePlus | |||
K224 | Ubiquitination | score1 | PhosphoSitePlus | |||
K228 | Acetylation | score1 | PhosphoSitePlus | |||
K228 | Ubiquitination | score1 | PhosphoSitePlus | |||
K232 | Acetylation | score1 | PhosphoSitePlus | |||
K232 | Ubiquitination | score1 | PhosphoSitePlus | |||
S237 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y239 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 15592455, 18083107 | ||
K243 | Acetylation | score1 | PhosphoSitePlus | |||
K243 | Ubiquitination | score1 | PhosphoSitePlus | |||
K245 | Ubiquitination | score1 | PhosphoSitePlus | |||
T248 | Phosphorylation | P06493 (CDK1) | score1 | PhosphoSitePlus | 18234856 | |
S249 | Phosphorylation | score1 | PhosphoSitePlus | |||
R269 | Methylation | score1 | PhosphoSitePlus | |||
K278 | Acetylation | score1 | PhosphoSitePlus | |||
K278 | Methylation | score1 | PhosphoSitePlus | |||
K278 | Ubiquitination | score1 | PhosphoSitePlus | |||
K284 | Ubiquitination | score1 | PhosphoSitePlus | |||
K305 | Ubiquitination | score1 | PhosphoSitePlus | |||
T309 | Phosphorylation | score1 | PhosphoSitePlus | |||
S310 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 24275569 | ||
K317 | Ubiquitination | score1 | PhosphoSitePlus | |||
K318 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K318 | Ubiquitination | score1 | PhosphoSitePlus | |||
S319 | Phosphorylation | score1 | PhosphoSitePlus | |||
T322 | Phosphorylation | score1 | PhosphoSitePlus | |||
K328 | Acetylation | score1 | PhosphoSitePlus | |||
K328 | Sumoylation | score1 | PhosphoSitePlus | |||
K328 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y10 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y239 | Phosphorylation | score0 | HPRD | 15592455, 16497976 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y232 | Phosphorylation | score1 | PhosphoSitePlus | |||
T233 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K27 | Ubiquitination | score1 | PhosphoSitePlus |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | P00338 (LDHA) | Y10 | Q16589 (CCNG2) | unknown | eFIP | 30745841 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
A2 | G2 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
K22 | N22 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc, tcga ] | |
T74 | S74 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ] | |
K81 | R81 | Biomuta | DOID:10534 / stomach cancer [ tcga ] | |
R157 | C157 | Biomuta | DOID:10534 / stomach cancer [ tcga ] | |
R269 | W269 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
K278 | N278 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S310 | P310 | Biomuta | DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ] |