iPTMnet Report for O96028 (NSD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O96028 / NSD2_HUMAN
Protein Name Histone-lysine N-methyltransferase NSD2
Gene Name Name: NSD2
Synonyms:KIAA1090,MMSET,TRX5,WHSC1;
Organism Homo sapiens (Human)

PRO ID PR:O96028
DAG View
PRO Name histone-lysine N-methyltransferase NSD2 (human)
Definition A histone-lysine N-methyltransferase NSD2 that is encoded in the genome of human.
Short Label hNSD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O96028 (NSD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
K78 Acetylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S102 Phosphorylation Q13315 (ATM) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 17525332, 21293379
T110 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T114 Phosphorylation PhosphoSitePlus   UniProt 19690332
T115 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S121 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S154 Phosphorylation PhosphoSitePlus
S172 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y175 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S177 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K191 Ubiquitination PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
K198 Acetylation PhosphoSitePlus
Y220 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
S280 O-Glycosylation GlyGen 30379171, 31492838
K292 Ubiquitination PhosphoSitePlus
K317 Acetylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus   UniProt 19690332
S377 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
K404 Acetylation PhosphoSitePlus
C406 Methylation IEDB 31844290
S407 Phosphorylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
T411 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
T422 Phosphorylation PhosphoSitePlus   UniProt 23186163
S437 Phosphorylation PhosphoSitePlus
K443 Methylation PhosphoSitePlus
T444 Phosphorylation PhosphoSitePlus
T445 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
T536 Phosphorylation PhosphoSitePlus
T544 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...19690332, 20068231
S555 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus
K582 Methylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
T587 Phosphorylation PhosphoSitePlus
K588 Methylation PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus   UniProt 23186163
K615 Methylation PhosphoSitePlus
S658 O-Glycosylation GlyGen 30379171, 31492838
K779 Acetylation PhosphoSitePlus
K781 Acetylation PhosphoSitePlus
K912 Sumoylation PhosphoSitePlus
K992 Ubiquitination PhosphoSitePlus
K1059 Ubiquitination PhosphoSitePlus
K1066 Ubiquitination PhosphoSitePlus
K1069 Sumoylation PhosphoSitePlus
K1133 Ubiquitination PhosphoSitePlus
K1207 Methylation PhosphoSitePlus
S1209 O-Glycosylation GlyGen 30379171
T1210 O-Glycosylation GlyGen 30379171
S1213 Phosphorylation PhosphoSitePlus
S1214 Phosphorylation PhosphoSitePlus
K1231 Acetylation PhosphoSitePlus
S1238 Phosphorylation PhosphoSitePlus
K1272 Acetylation PhosphoSitePlus
T1316 Phosphorylation PhosphoSitePlus
S1332 Phosphorylation PhosphoSitePlus
S1335 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S56 Phosphorylation HPRD 19691289
S102 Phosphorylation HPRD 17525332, 20068231
T110 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
T114 Phosphorylation HPRD 19413330, 20068231
T115 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S121 Phosphorylation HPRD 19413330, 18669648, 20068231
S172 Phosphorylation HPRD 18669648, 20068231
Y175 Phosphorylation HPRD 18669648, 20068231
S177 Phosphorylation HPRD 18669648
S376 Phosphorylation HPRD 20068231
S377 Phosphorylation HPRD 20068231
S380 Phosphorylation HPRD 20068231
T422 Phosphorylation HPRD 19413330
S437 Phosphorylation HPRD 19007248, 19691289
S495 Phosphorylation HPRD 20068231
T544 Phosphorylation HPRD 19413330, 17081983, 19691289, ...18452278, 18669648, 19007248, 20068231
S580 Phosphorylation HPRD 19413330
S583 Phosphorylation HPRD 19413330
T587 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
S56 Phosphorylation HPRD 19691289
S102 Phosphorylation HPRD 17525332, 20068231
T110 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
T114 Phosphorylation HPRD 19413330, 20068231
T115 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S121 Phosphorylation HPRD 19413330, 18669648, 20068231
S172 Phosphorylation HPRD 18669648, 20068231
Y175 Phosphorylation HPRD 18669648, 20068231
S177 Phosphorylation HPRD 18669648
S376 Phosphorylation HPRD 20068231
S377 Phosphorylation HPRD 20068231
S380 Phosphorylation HPRD 20068231
T422 Phosphorylation HPRD 19413330
S437 Phosphorylation HPRD 19007248, 19691289
S495 Phosphorylation HPRD 20068231
T544 Phosphorylation HPRD 19413330, 17081983, 19691289, ...18452278, 18669648, 19007248, 20068231
S580 Phosphorylation HPRD 19413330
S583 Phosphorylation HPRD 19413330
T587 Phosphorylation HPRD 19413330
S618 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S56 Phosphorylation HPRD 19691289
S102 Phosphorylation HPRD 17525332, 20068231
T110 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
T114 Phosphorylation HPRD 19413330, 20068231
T115 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S121 Phosphorylation HPRD 19413330, 18669648, 20068231
S172 Phosphorylation HPRD 18669648, 20068231
Y175 Phosphorylation HPRD 18669648, 20068231
S177 Phosphorylation HPRD 18669648
S193 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S376 Phosphorylation HPRD 20068231
S377 Phosphorylation HPRD 20068231
S380 Phosphorylation HPRD 20068231
T422 Phosphorylation HPRD 19413330
S437 Phosphorylation HPRD 19007248, 19691289
S495 Phosphorylation HPRD 20068231
T544 Phosphorylation HPRD 19413330, 17081983, 19691289, ...18452278, 18669648, 19007248, 20068231
S580 Phosphorylation HPRD 19413330
S583 Phosphorylation HPRD 19413330
T587 Phosphorylation HPRD 19413330
S617 Phosphorylation PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049680 (hNSD2/Phos:1) pS102 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O96028 (NSD2) S102 Q14676 (MDC1) unknown eFIP 21293379


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S30 I30 Biomuta DOID:3571 / liver cancer [ cosmic ]
S102 F102 Biomuta DOID:4159 / skin cancer [ cosmic ]
S172 N172 Biomuta DOID:3571 / liver cancer [ cosmic ]
S172 C172 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S177 F177 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K191 T191 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S193 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S194 I194 Biomuta DOID:263 / kidney cancer [ cosmic ]
S194 R194 Biomuta DOID:1324 / lung cancer [ cosmic ]
S231 L231 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S376 F376 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S447 Y447 Biomuta [ cosmic ]
S479 L479 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S580 L580 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S580 P580 Biomuta DOID:1612 / breast cancer [ cosmic, cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, cosmic, icgc, cosmic, cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S580 * Biomuta DOID:1319 / brain cancer [ cosmic ]
K1069 N1069 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1209 L1209 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1332 L1332 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]