Protein Information

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UniProt AC / UniProt ID O96013 / PAK4_HUMAN
Protein Name Serine/threonine-protein kinase PAK 4
Gene Name Name: PAK4
Synonyms:KIAA1142;
Organism Homo sapiens (Human)

PRO ID PR:O96013
DAG View
PRO Name serine/threonine-protein kinase PAK 4 (human)
Definition A serine/threonine-protein kinase PAK 4 that is encoded in the genome of human.
Short Label hPAK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O96013 (PAK4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K31 Ubiquitination PhosphoSitePlus
T33 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
S74 Phosphorylation PhosphoSitePlus
K78 Methylation PhosphoSitePlus   UniProt 24129315
S93 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
S99 Phosphorylation Q15139 (PRKD1) phospho.ELM   PhosphoSitePlus   RLIMS-P 23841590, 26068882, 17192257
S104 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17192257, 19369195
R126 Methylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
S148 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17192257, 19369195
S167 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17192257, 19369195
S181 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 23186163, ...22238634, 19369195, 17192257, 18669648, 24275569, 19690332
T187 Phosphorylation PhosphoSitePlus   UniProt 19369195
S195 Phosphorylation PhosphoSitePlus   UniProt 19369195
T207 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17192257
Y208 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R254 Methylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
S267 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17192257
T277 Phosphorylation PhosphoSitePlus
S291 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17192257, 19369195
R341 Methylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
K455 Acetylation PhosphoSitePlus
K467 Acetylation PhosphoSitePlus
S474 Phosphorylation O96013 (PAK4) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 21406692, 23934187, ...23186163, 17081983, 26598620, 19369195, 17292838, 24501395, 17192257, 22710715, 18669648, 20926745, 28178642, 23841590, 11668177, 19690332, 20068231, 22653441
T478 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y480 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S488 Phosphorylation PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S41 Phosphorylation HPRD 18691976
S99 Phosphorylation O96013 (PAK4) HPRD   PRO 23841590, 17192257
S104 Phosphorylation O96013 (PAK4) HPRD 18691976, 17192257
S142 Phosphorylation HPRD 18691976
S148 Phosphorylation O96013 (PAK4) HPRD 19651622, 18691976, 17192257, ...20068231
S167 Phosphorylation O96013 (PAK4) HPRD 18691976, 17192257
S181 Phosphorylation O96013 (PAK4) HPRD 18691976, 18452278, 19651622, ...17322306, 18669648, 18707149, 20068231
T187 Phosphorylation HPRD 19651622, 18691976
T207 Phosphorylation O96013 (PAK4) HPRD 18691976, 18212344, 17192257
Y208 Phosphorylation HPRD 18669648
S242 Phosphorylation HPRD 18691976
S258 Phosphorylation O96013 (PAK4) HPRD 18691976, 17192257
S267 Phosphorylation HPRD 18691976
T277 Phosphorylation HPRD 18691976
S291 Phosphorylation O96013 (PAK4) HPRD 18691976, 17192257, 20068231
S342 Phosphorylation HPRD 20068231
S474 Phosphorylation HPRD   PRO 18691976, 20230923, 18452278, ...19651622, 18669648, 18707149, 23841590, 15345747, 20068231
T478 Phosphorylation O96013 (PAK4) HPRD 18691976, 18669648, 17192257, ...20068231
Y480 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S41 Phosphorylation HPRD 18691976
S105 Phosphorylation O96013 (PAK4) HPRD 18691976, 17192257
S114 Phosphorylation HPRD 18691976
T124 Phosphorylation HPRD 18691976
S138 Phosphorylation O96013 (PAK4) HPRD 18691976, 17192257, 20068231
S189 Phosphorylation HPRD 20068231
S321 Phosphorylation HPRD 18691976, 20230923, 18452278, ...19651622, 18669648, 18707149, 15345747, 20068231
T325 Phosphorylation O96013 (PAK4) HPRD 18691976, 18669648, 17192257, ...20068231
Y327 Phosphorylation HPRD 18669648


O96013 (PAK4) as PTM Enzyme



Substrate Site Score Source PMID
O96013-1 (PAK4) S99 HPRD 17192257
O96013-1 (PAK4) S104 HPRD 18691976, 17192257
O96013-3 (PAK4) S105 HPRD 18691976, 17192257
O96013-3 (PAK4) S138 HPRD 18691976, 17192257, 20068231
O96013-1 (PAK4) S148 HPRD 19651622, 18691976, 17192257, ...20068231
O96013-1 (PAK4) S167 HPRD 18691976, 17192257
O96013-1 (PAK4) S181 HPRD 18691976, 18452278, 19651622, ...17322306, 18669648, 18707149, 20068231
O96013-1 (PAK4) T207 HPRD 18691976, 18212344, 17192257
O96013-1 (PAK4) S258 HPRD 18691976, 17192257
O96013-1 (PAK4) S291 HPRD 18691976, 17192257, 20068231
O96013-3 (PAK4) T325 HPRD 18691976, 18669648, 17192257, ...20068231
O96013 (PAK4) S474 PhosphoSitePlus   Signor   UniProt 11668177, 20926745, 17081983
O96013-1 (PAK4) T478 HPRD 18691976, 18669648, 17192257, ...20068231
P03372 (ESR1) S305 PhosphoSitePlus 26554417
P04637 (TP53) S215 RLIMS-P+ 27496712
P18084 (ITGB5) S759 neXtProt   PhosphoSitePlus   Signor 20507994
P18084 (ITGB5) S762 neXtProt   PhosphoSitePlus   Signor 20507994
P35222 (CTNNB1) S675 PhosphoSitePlus   Signor 22173096, 26068882
P49023-2 (PXN) S272 neXtProt   PhosphoSitePlus   Signor 20406887
P62826 (RAN) S135 neXtProt   PhosphoSitePlus   Signor 20805321
Q15796 (SMAD2) S465 RLIMS-P+ 23934187
Q92934 (BAD) S75 neXtProt 11278822
Q92974-2 (ARHGEF2) S885 PhosphoSitePlus 20406887
Q92974 (ARHGEF2) S886 neXtProt 15827085, 20406887
Q93045 (STMN2) S50 PhosphoSitePlus 23893240


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044819 (hPAK4/iso:1/Phos:1) pS99,pS474 PRO 23841590


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000044819 (hPAK4/iso:1/Phos:1) Interaction PR:P61981 (hYWHAG) PRO 23695676


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S41 G41 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y208 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R254 Q254 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
R341 C341 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S474 L474 Biomuta DOID:363 / uterine cancer [ tcga ]
T478 M478 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ tcga ] DOID:5041 / esophageal cancer [ icgc ]