iPTMnet Report O96013 PAK4

Protein Information

UniProt AC / UniProt ID	O96013 / PAK4_HUMAN
Protein Name	Serine/threonine-protein kinase PAK 4
Gene Name	Name: PAK4 Synonyms:KIAA1142;
Organism	Homo sapiens (Human)

PRO ID	PR:O96013 DAG View
PRO Name	serine/threonine-protein kinase PAK 4 (human)
Definition	A serine/threonine-protein kinase PAK 4 that is encoded in the genome of human.
Short Label	hPAK4
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O96013 (PAK4) as Substrate

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
K31	Ubiquitination		score1	PhosphoSitePlus
T33	Phosphorylation		score1	PhosphoSitePlus
S41	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976, 23186163, 19369195
S74	Phosphorylation		score1	PhosphoSitePlus
K78	Methylation		score2	PhosphoSitePlus UniProt	24129315
S93	Phosphorylation		score1	PhosphoSitePlus
S97	Phosphorylation		score1	PhosphoSitePlus
S99	Phosphorylation	Q15139 (PRKD1)	score4	phospho.ELM PhosphoSitePlus RLIMS-P	23841590, 26068882, 35593474, ...17192257
S104	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 17192257, 19369195
R126	Methylation		score1	PhosphoSitePlus
S142	Phosphorylation		score1	PhosphoSitePlus
S148	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 17192257, 19369195
S167	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 17192257, 19369195
S181	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	18691976, 21406692, 23186163, ...24275569, 19369195, 17192257, 18669648, 22238634, 19690332
T187	Phosphorylation		score2	PhosphoSitePlus UniProt	19369195
S195	Phosphorylation		score2	PhosphoSitePlus UniProt	19369195
T207	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	23186163, 17192257
Y208	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
R254	Methylation		score1	PhosphoSitePlus
S258	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976, 19369195
S267	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 17192257
T277	Phosphorylation		score1	PhosphoSitePlus
S291	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 17192257, 19369195
R341	Methylation		score1	PhosphoSitePlus
S443	Phosphorylation		score1	PhosphoSitePlus
S445	Phosphorylation		score1	PhosphoSitePlus
K455	Acetylation		score1	PhosphoSitePlus
K467	Acetylation		score1	PhosphoSitePlus
K473	Methylation		score1	PhosphoSitePlus
S474	Phosphorylation	O96013 (PAK4)	score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18691976, 21406692, 23934187, ...23186163, 17081983, 26598620, 11668177, 24501395, 17192257, 22710715, 18669648, 20926745, 20068231, 19369195, 23841590, 22653441, 19690332, 28178642, 34085786
T478	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
Y480	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S488	Phosphorylation		score1	PhosphoSitePlus
K540	Ubiquitination		score1	PhosphoSitePlus

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S41	Phosphorylation		score0	HPRD	18691976
S99	Phosphorylation	O96013 (PAK4)	score4	HPRD PRO	23841590, 17192257
S104	Phosphorylation	O96013 (PAK4)	score0	HPRD	18691976, 17192257
S142	Phosphorylation		score0	HPRD	18691976
S148	Phosphorylation	O96013 (PAK4)	score0	HPRD	19651622, 18691976, 17192257, ...20068231
S167	Phosphorylation	O96013 (PAK4)	score0	HPRD	18691976, 17192257
S181	Phosphorylation	O96013 (PAK4)	score0	HPRD	18691976, 18452278, 19651622, ...17322306, 18669648, 18707149, 20068231
T187	Phosphorylation		score0	HPRD	19651622, 18691976
T207	Phosphorylation	O96013 (PAK4)	score0	HPRD	18691976, 18212344, 17192257
Y208	Phosphorylation		score0	HPRD	18669648
S242	Phosphorylation		score0	HPRD	18691976
S258	Phosphorylation	O96013 (PAK4)	score0	HPRD	18691976, 17192257
S267	Phosphorylation		score0	HPRD	18691976
T277	Phosphorylation		score0	HPRD	18691976
S291	Phosphorylation	O96013 (PAK4)	score0	HPRD	18691976, 17192257, 20068231
S342	Phosphorylation		score0	HPRD	20068231
S474	Phosphorylation		score4	HPRD PRO	18691976, 20230923, 18452278, ...19651622, 18669648, 18707149, 23841590, 15345747, 20068231
T478	Phosphorylation	O96013 (PAK4)	score0	HPRD	18691976, 18669648, 17192257, ...20068231
Y480	Phosphorylation		score0	HPRD	18669648

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S41	Phosphorylation		score0	HPRD	18691976
S105	Phosphorylation	O96013 (PAK4)	score0	HPRD	18691976, 17192257
S114	Phosphorylation		score0	HPRD	18691976
T124	Phosphorylation		score0	HPRD	18691976
S138	Phosphorylation	O96013 (PAK4)	score0	HPRD	18691976, 17192257, 20068231
S189	Phosphorylation		score0	HPRD	20068231
S321	Phosphorylation		score0	HPRD	18691976, 20230923, 18452278, ...19651622, 18669648, 18707149, 15345747, 20068231
T325	Phosphorylation	O96013 (PAK4)	score0	HPRD	18691976, 18669648, 17192257, ...20068231
Y327	Phosphorylation		score0	HPRD	18669648

O96013 (PAK4) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
O96013-1 (PAK4)	S99	score0	HPRD	17192257
O96013-1 (PAK4)	S104	score0	HPRD	18691976, 17192257
O96013-3 (PAK4)	S105	score0	HPRD	18691976, 17192257
O96013-3 (PAK4)	S138	score0	HPRD	18691976, 17192257, 20068231
O96013-1 (PAK4)	S148	score0	HPRD	19651622, 18691976, 17192257, ...20068231
O96013-1 (PAK4)	S167	score0	HPRD	18691976, 17192257
O96013-1 (PAK4)	S181	score0	HPRD	18691976, 18452278, 19651622, ...17322306, 18669648, 18707149, 20068231
O96013-1 (PAK4)	T207	score0	HPRD	18691976, 18212344, 17192257
O96013-1 (PAK4)	S258	score0	HPRD	18691976, 17192257
O96013-1 (PAK4)	S291	score0	HPRD	18691976, 17192257, 20068231
O96013-3 (PAK4)	T325	score0	HPRD	18691976, 18669648, 17192257, ...20068231
O96013 (PAK4)	S474	score4	PhosphoSitePlus Signor UniProt	11668177, 20926745, 17081983
O96013-1 (PAK4)	T478	score0	HPRD	18691976, 18669648, 17192257, ...20068231
P03372 (ESR1)	S305	score2	PhosphoSitePlus	26554417
P04637 (TP53)	S215	score2	RLIMS-P+	27496712
P07954 (FH)	S46	score1	Signor	30683654
P18084 (ITGB5)	S759	score3	neXtProt PhosphoSitePlus Signor	20507994
P18084 (ITGB5)	S762	score3	neXtProt PhosphoSitePlus Signor	20507994
P35222 (CTNNB1)	S675	score4	PhosphoSitePlus Signor	22173096, 26068882
P49023-2 (PXN)	S272	score3	neXtProt PhosphoSitePlus Signor	20406887
P62826 (RAN)	S135	score3	neXtProt PhosphoSitePlus Signor	20805321
Q15796 (SMAD2)	S465	score2	RLIMS-P+	23934187
Q92934 (BAD)	S75	score2	neXtProt	11278822
Q92974-2 (ARHGEF2)	S885	score2	PhosphoSitePlus	20406887
Q92974 (ARHGEF2)	S886	score3	neXtProt	15827085, 20406887
Q93045 (STMN2)	S50	score2	PhosphoSitePlus	23893240

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000044819 (hPAK4/iso:1/Phos:1)	pS99,pS474		PRO	23841590

Proteoform PPIs

	Protein 1	Relation	Protein 2	Source	PMID
	PR:000044819 (hPAK4/iso:1/Phos:1)	Interaction	PR:P61981 (hYWHAG)	PRO	23695676

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
S41	G41	Biomuta	DOID:1612 / breast cancer [ cosmic ]
Y208	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
R254	Q254	Biomuta	DOID:4362 / cervical cancer [ cosmic, icgc ]
S321	L321	Biomuta	DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T325	M325	Biomuta	DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
R341	H341	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S474	L474	Biomuta	DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T478	M478	Biomuta	DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for O96013 (PAK4)

Protein Information

Interactive Sequence View

O96013 (PAK4) as Substrate

O96013 (PAK4) as PTM Enzyme

Proteoforms

Proteoform PPIs

PTM sites affected in variants