iPTMnet Report for O95997 (PTTG1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95997 / PTTG1_HUMAN
Protein Name Securin
Gene Name Name: PTTG1
Synonyms:EAP1,PTTG,TUTR1;
Organism Homo sapiens (Human)

PRO ID PR:O95997
DAG View
PRO Name securin (human)
Definition A securin that is encoded in the genome of human.
Short Label hPTTG1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95997 (PTTG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
A2 Acetylation UniProt 22814378
Y6 Phosphorylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
T16 Phosphorylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
K48 Acetylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
T60 Phosphorylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
T66 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
Y111 Phosphorylation PhosphoSitePlus
S165 Phosphorylation P27361 (MAPK3) , P06493 (CDK1) , P28482 (MAPK1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20058876, 16964243, 18767875, ...15302935, 19664995, 21937724, 19651622, 18669648, 10656688, 10906323, 20068231, 20068230
S171 Phosphorylation PhosphoSitePlus
S181 Phosphorylation HPRD 20068231
S183 Phosphorylation PhosphoSitePlus
S184 Phosphorylation HPRD   PhosphoSitePlus 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048971 (hPTTG1/UbiqLys+) ub PRO


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O60566 (hBUB1B) Interaction PR:O95997 (hPTTG1) PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T43 I43 Biomuta DOID:3571 / liver cancer [ cosmic ]
T60 N60 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S171 C171 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S184 N184 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]