iPTMnet Report for O95985 (TOP3B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95985 / TOP3B_HUMAN
Protein Name DNA topoisomerase 3-beta-1
Gene Name Name: TOP3B
Synonyms:TOP3B1;
Organism Homo sapiens (Human)

PRO ID PR:O95985
DAG View
PRO Name DNA topoisomerase 3-beta-1 (human)
Definition A DNA topoisomerase 3-beta-1 that is encoded in the genome of human.
Short Label hTOP3B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95985 (TOP3B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K19 Ubiquitination PhosphoSitePlus
Y70 Phosphorylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
C109 Methylation IEDB 31844290
K139 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K281 Acetylation PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
T501 Phosphorylation PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
C646 Methylation IEDB 31844290
S772 Phosphorylation PhosphoSitePlus
S788 Phosphorylation PhosphoSitePlus
R824 Methylation PhosphoSitePlus
R829 Methylation PhosphoSitePlus
K853 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K637 R637 Biomuta DOID:5041 / esophageal cancer [ cosmic ]