iPTMnet Report for O95983 (MBD3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95983 / MBD3_HUMAN
Protein Name Methyl-CpG-binding domain protein 3
Gene Name Name: MBD3
Organism Homo sapiens (Human)

PRO ID PR:O95983
DAG View
PRO Name methyl-CpG-binding domain protein 3 (human)
Definition A methyl-CpG-binding domain protein 3 that is encoded in the genome of human.
Short Label hMBD3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95983 (MBD3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 12354758
S24 Phosphorylation O14965 (AURKA) PhosphoSitePlus   Signor 12354758
Y35 Phosphorylation PhosphoSitePlus
Y36 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
S56 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
T61 Phosphorylation PhosphoSitePlus
T66 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
S85 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 23186163, 12354758, ...18669648, 20068231
S85 Phosphorylation O14965 (AURKA) PhosphoSitePlus   Signor 12354758
S86 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
K109 Acetylation PhosphoSitePlus
K109 Sumoylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus   UniProt 19690332, 20068231
K157 Ubiquitination PhosphoSitePlus
T221 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K4 Acetylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 N7 Biomuta DOID:4159 / skin cancer [ cosmic ]
S39 N39 Biomuta DOID:4159 / skin cancer [ cosmic ]
S45 G45 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S77 N77 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S85 F85 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T97 M97 Biomuta [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1115 / sarcoma [ icgc ]