iPTMnet Report for O95864 (FADS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95864 / FADS2_HUMAN
Protein Name Acyl-CoA 6-desaturase
Gene Name Name: FADS2
Organism Homo sapiens (Human)

PRO ID PR:O95864
DAG View
PRO Name acyl-CoA 6-desaturase (human)
Definition An acyl-CoA 6-desaturase that is encoded in the genome of human.
Short Label hFADS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95864 (FADS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K28 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
C364 Methylation IEDB 31844290
K398 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
C407 Methylation IEDB 31844290
K409 Ubiquitination PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K42 N42 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C364 Y364 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
C407 S407 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K409 N409 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]