Protein Information

Cytoscape View


UniProt AC / UniProt ID O95835 / LATS1_HUMAN
Protein Name Serine/threonine-protein kinase LATS1
Gene Name Name: LATS1
Synonyms:WARTS;
Organism Homo sapiens (Human)

PRO ID PR:O95835
DAG View
PRO Name serine/threonine-protein kinase LATS1 (human)
Definition A serine/threonine-protein kinase LATS1 that is encoded in the genome of human.
Short Label hLATS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95835 (LATS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T17 Phosphorylation PhosphoSitePlus   RLIMS-P 33270624
Y23 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
Y143 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus   RLIMS-P 33270624
R243 Methylation PhosphoSitePlus
S244 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
T246 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
R252 Methylation PhosphoSitePlus
T255 Phosphorylation PhosphoSitePlus
R259 Methylation PhosphoSitePlus
T261 Phosphorylation PhosphoSitePlus
T262 Phosphorylation PhosphoSitePlus
K275 Methylation PhosphoSitePlus
Y277 Phosphorylation PhosphoSitePlus
S278 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 33270624, 18220336
Y283 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
S464 Phosphorylation Q9H093 (NUAK2) , O60285 (NUAK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 33270624, 23186163, 15302935, ...18669648, 19927127
T490 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus 12372621
S580 Phosphorylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
T612 Phosphorylation PhosphoSitePlus
S613 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12372621, 15688006, 33270624, ...23186163
T616 Phosphorylation PhosphoSitePlus
S633 Phosphorylation phospho.ELM   PhosphoSitePlus 15688006
S635 Phosphorylation PhosphoSitePlus
K662 Ubiquitination PhosphoSitePlus
S674 Phosphorylation O95835 (LATS1) phospho.ELM   PhosphoSitePlus   UniProt 17525332, 15688006
K688 Ubiquitination PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
T735 Phosphorylation PhosphoSitePlus
K751 Sumoylation PhosphoSitePlus
S792 Phosphorylation PhosphoSitePlus
K830 Sumoylation PhosphoSitePlus
S864 Phosphorylation PhosphoSitePlus
S872 Phosphorylation Q13188 (STK3) neXtProt   PhosphoSitePlus 15688006
S909 Phosphorylation Q13043 (STK4) , Q13188 (STK3) , O95835 (LATS1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 29093443, 21555462, 25723520, ...27847303, 15688006, 31569999, 29758456, 30863499, 29317530, 26108669
T967 Phosphorylation Q13188 (STK3) neXtProt   PhosphoSitePlus 15688006
K976 Ubiquitination PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus
K1005 Ubiquitination PhosphoSitePlus
T1012 Phosphorylation Q13188 (STK3) neXtProt   PhosphoSitePlus 15688006
K1029 Ubiquitination PhosphoSitePlus
K1046 Ubiquitination PhosphoSitePlus
S1049 Phosphorylation O95835 (LATS1) PhosphoSitePlus 15688006
T1060 Phosphorylation Q13188 (STK3) neXtProt   PhosphoSitePlus 15688006
Y1076 Phosphorylation PhosphoSitePlus
T1079 Phosphorylation Q13043 (STK4) , Q13188 (STK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 33672268, 24356468, 27555231, ...28087714, 15688006, 27847303, 25723520, 30800215, 30863499, 26108669
S1107 Phosphorylation PhosphoSitePlus
S1111 Phosphorylation phospho.ELM   PhosphoSitePlus 15688006
Site PTM Type PTM Enzyme Score Source PMID
S244 Phosphorylation HPRD 19413330
T246 Phosphorylation HPRD 19413330, 18691976, 18669648, ...19664995
T261 Phosphorylation HPRD 18691976
S278 Phosphorylation HPRD 18669648
S334 Phosphorylation HPRD 17322306
S335 Phosphorylation HPRD 17322306
S462 Phosphorylation HPRD 19651622, 18691976, 18452278
S464 Phosphorylation HPRD 17322306, 18691976, 18669648, ...19413330, 19651622
T490 Phosphorylation P06493 (CDK1) HPRD 12372621
T611 Phosphorylation HPRD 18691976
S613 Phosphorylation P06493 (CDK1) HPRD 12372621, 18691976
S674 Phosphorylation HPRD 17525332
S1111 Phosphorylation HPRD 18691976


O95835 (LATS1) as PTM Enzyme



Substrate Site Score Source PMID
O14974 (PPP1R12A) S445 neXtProt 22641346
O95835 (LATS1) S674 PhosphoSitePlus 15688006
O95835 (LATS1) S909 PhosphoSitePlus 26108669
O95835 (LATS1) S1049 PhosphoSitePlus 15688006
P04049 (RAF1) S259 PhosphoSitePlus 24929361
P46937-2 (YAP1) S61 PhosphoSitePlus 20048001
P46937-2 (YAP1) S109 PhosphoSitePlus 20048001
P46937 (YAP1) S127 neXtProt   PhosphoSitePlus   Signor 20048001, 25751139, 18158288, ...18640976, 22658639, 18369314, 20153295
P46937-2 (YAP1) S164 PhosphoSitePlus 20048001
P46937-2 (YAP1) S381 PhosphoSitePlus 20048001
P46937 (YAP1) S397 Signor 20048001
Q02241 (KIF23) S716 PhosphoSitePlus 25786116, 25658096
Q02241 (KIF23) S814 PhosphoSitePlus 25658096
Q8NHZ8 (CDC26) T7 PhosphoSitePlus 25723520
Q9GZV5 (WWTR1) S89 neXtProt   Signor 21808241, 20412773, 22658639
Q9NQS7 (INCENP) S894 RLIMS-P+ 27512725