iPTMnet Report for O95831 (AIFM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95831 / AIFM1_HUMAN
Protein Name Apoptosis-inducing factor 1, mitochondrial precursor
Gene Name Name: AIFM1
Synonyms:AIF,PDCD8;
Organism Homo sapiens (Human)

PRO ID PR:O95831
DAG View
PRO Name apoptosis-inducing factor 1, mitochondrial (human)
Definition An apoptosis-inducing factor 1, mitochondrial that is encoded in the genome of human.
Short Label hAIFM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95831 (AIFM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S56 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
S60 O-Glycosylation GlyGen 32119511, 30444036, 34725712, ...29351928
S60 Phosphorylation PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
Y95 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
T105 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163
K109 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S118 Phosphorylation PhosphoSitePlus   UniProt 24275569
S176 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
T190 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K244 Acetylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus   UniProt 22103349
T263 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S268 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
K278 Ubiquitination PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
T281 Phosphorylation PhosphoSitePlus   RLIMS-P 33867848
S292 Phosphorylation PhosphoSitePlus   UniProt 23186163
K295 Acetylation PhosphoSitePlus
T328 Phosphorylation PhosphoSitePlus
K337 Acetylation PhosphoSitePlus
Y347 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus   UniProt 24275569
S375 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
Y443 Phosphorylation PhosphoSitePlus
K518 Ubiquitination PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
T521 Phosphorylation PhosphoSitePlus   UniProt 24275569
S524 Phosphorylation PhosphoSitePlus   UniProt 24275569
T526 Phosphorylation PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus   UniProt 24275569
S532 Phosphorylation PhosphoSitePlus
T542 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
R569 Methylation PhosphoSitePlus
K593 Acetylation PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T105 Phosphorylation HPRD 18691976
S268 Phosphorylation HPRD 18691976, 18669648, 20068231
T328 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T101 Phosphorylation HPRD 18691976
S264 Phosphorylation HPRD 18691976, 18669648, 20068231
T324 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S100 L100 Biomuta DOID:1324 / lung cancer [ cosmic ]
S100 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S118 L118 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S176 L176 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S182 L182 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T190 A190 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K232 N232 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K255 M255 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K278 N278 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S279 I279 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K295 N295 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y347 F347 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S371 F371 Biomuta DOID:4159 / skin cancer [ icgc, tcga ]
S416 L416 Biomuta DOID:4159 / skin cancer [ cosmic ]
S519 Y519 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T521 K521 Biomuta DOID:1612 / breast cancer [ cosmic ]
S532 N532 Biomuta DOID:1324 / lung cancer [ cosmic ]
R569 M569 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K593 N593 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K606 E606 Biomuta DOID:9256 / colorectal cancer [ cosmic ]