iPTMnet Report for O95819 (MAP4K4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95819 / M4K4_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase kinase 4
Gene Name Name: MAP4K4
Synonyms:HGK,KIAA0687,NIK;
Organism Homo sapiens (Human)

PRO ID PR:O95819
DAG View
PRO Name mitogen-activated protein kinase kinase kinase kinase 4 (human)
Definition A mitogen-activated protein kinase kinase kinase kinase 4 that is encoded in the genome of human.
Short Label hMAP4K4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95819 (MAP4K4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19369195, 22814378
S5 Phosphorylation PhosphoSitePlus   UniProt 19369195
S17 Phosphorylation PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
Y36 Phosphorylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
Y86 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
T124 Phosphorylation PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
T181 Phosphorylation phospho.ELM   PhosphoSitePlus 17192257
T187 Phosphorylation PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
Y323 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
T351 Phosphorylation PhosphoSitePlus
Y467 Phosphorylation PhosphoSitePlus
Y520 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
R546 Methylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
S550 Phosphorylation PhosphoSitePlus
Y560 Phosphorylation PhosphoSitePlus
T576 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S602 Phosphorylation phospho.ELM   PhosphoSitePlus 17192257
S604 Phosphorylation PhosphoSitePlus
S608 Phosphorylation UniProt 18691976, 18669648
V625 Phosphorylation UniProt 18669648
T627 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T628 Phosphorylation PhosphoSitePlus
S629 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...17192257, 18669648
S631 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...15302935, 17192257, 18669648
S639 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...18220336, 17192257, 18691976, 18669648, 24275569
S644 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
S649 Phosphorylation PhosphoSitePlus
S656 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S677 Phosphorylation PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
S680 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
S684 Phosphorylation PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus
S688 Phosphorylation PhosphoSitePlus
S692 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S696 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S698 Phosphorylation PhosphoSitePlus
S700 Phosphorylation PhosphoSitePlus   UniProt 23186163
S708 Phosphorylation PhosphoSitePlus
S709 Phosphorylation PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus
S712 Phosphorylation PhosphoSitePlus   UniProt 18691976
S715 Phosphorylation PhosphoSitePlus   UniProt 23186163
P716 Phosphorylation UniProt 18691976, 18669648
S717 Phosphorylation PhosphoSitePlus
V733 Phosphorylation UniProt 18669648
K738 Ubiquitination PhosphoSitePlus
T743 Phosphorylation PhosphoSitePlus
S791 Phosphorylation PhosphoSitePlus   UniProt 24275569
S800 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S801 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17192257
S805 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 19369195, ...15302935, 17192257, 18669648, 19690332, 20068231
T809 Phosphorylation PhosphoSitePlus
S811 Phosphorylation PhosphoSitePlus
S823 Phosphorylation PhosphoSitePlus   UniProt 23186163
T828 Phosphorylation PhosphoSitePlus   UniProt 23186163
S830 Phosphorylation PhosphoSitePlus
K831 Ubiquitination PhosphoSitePlus
T834 Phosphorylation PhosphoSitePlus
T840 O-Glycosylation GlyGen 28411811, 29351928, 35132862, ...34019948
T840 Phosphorylation PhosphoSitePlus
S842 Phosphorylation PhosphoSitePlus
T846 Phosphorylation PhosphoSitePlus
K849 Methylation PhosphoSitePlus
K849 Ubiquitination PhosphoSitePlus
K851 Methylation PhosphoSitePlus
K851 Ubiquitination PhosphoSitePlus
S852 Phosphorylation PhosphoSitePlus   UniProt 23186163
S853 Phosphorylation PhosphoSitePlus
S854 Phosphorylation PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus   UniProt 23186163
T857 Phosphorylation PhosphoSitePlus
S868 Phosphorylation PhosphoSitePlus
S870 Phosphorylation PhosphoSitePlus
S871 Phosphorylation PhosphoSitePlus
T873 Phosphorylation PhosphoSitePlus
T874 Phosphorylation PhosphoSitePlus
T876 Phosphorylation PhosphoSitePlus
S877 Phosphorylation PhosphoSitePlus
S882 O-Glycosylation GlyGen 28411811, 29351928, 35132862, ...34019948
K898 Ubiquitination PhosphoSitePlus
S900 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 17192257
T907 Phosphorylation PhosphoSitePlus
S913 Phosphorylation PhosphoSitePlus   UniProt 23186163
T915 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K957 Ubiquitination PhosphoSitePlus
Y992 Phosphorylation PhosphoSitePlus
S995 Phosphorylation PhosphoSitePlus
K1010 Ubiquitination PhosphoSitePlus
K1053 Ubiquitination PhosphoSitePlus
K1057 Ubiquitination PhosphoSitePlus
K1070 Ubiquitination PhosphoSitePlus
Y1143 Phosphorylation PhosphoSitePlus
T1146 Phosphorylation PhosphoSitePlus
K1152 Ubiquitination PhosphoSitePlus
K1179 Ubiquitination PhosphoSitePlus
K1198 Ubiquitination PhosphoSitePlus
K1204 Ubiquitination PhosphoSitePlus
K1212 Ubiquitination PhosphoSitePlus
S1224 Phosphorylation PhosphoSitePlus
Y1227 Phosphorylation PhosphoSitePlus
T1230 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation HPRD 19664994
T319 Phosphorylation HPRD 18691976
Y321 Phosphorylation HPRD 18691976
S324 Phosphorylation HPRD 18691976, 18452278
S326 Phosphorylation HPRD 18691976, 18452278
S350 Phosphorylation HPRD 18691976
T351 Phosphorylation HPRD 18691976
T596 Phosphorylation HPRD 19651622, 18691976, 18669648
T597 Phosphorylation HPRD 19651622
S598 Phosphorylation HPRD 19651622, 18691976, 18669648, ...15302935
S600 Phosphorylation HPRD 19651622, 18691976, 18669648, ...15302935
S608 Phosphorylation HPRD 19651622, 18691976, 18669648, ...19664995, 20068231
S613 Phosphorylation HPRD 18691976
S618 Phosphorylation HPRD 18691976
S625 Phosphorylation HPRD 18691976, 18669648
S628 Phosphorylation HPRD 18669648
S647 Phosphorylation HPRD 18691976
S662 Phosphorylation HPRD 18691976, 17525332
S666 Phosphorylation HPRD 17525332
S682 Phosphorylation HPRD 18691976
S685 Phosphorylation HPRD 18691976
S773 Phosphorylation HPRD 18691976
S774 Phosphorylation HPRD 15345747
S778 Phosphorylation HPRD 18691976, 18578522, 20058876, ...15302935, 19664995, 18452278, 19664994, 18669648, 20068231
S784 Phosphorylation HPRD 18691976
T801 Phosphorylation HPRD 18691976
S815 Phosphorylation HPRD 18691976
S825 Phosphorylation HPRD 19651622, 18691976
S828 Phosphorylation HPRD 19651622, 18691976
T830 Phosphorylation HPRD 18691976
S841 Phosphorylation HPRD 18691976
T880 Phosphorylation HPRD 18691976
S886 Phosphorylation HPRD 18691976
T888 Phosphorylation HPRD 18691976, 18669648
Site PTM Type PTM Enzyme Score Source PMID
S545 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
K742 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S608 Phosphorylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
T798 Phosphorylation PhosphoSitePlus
S800 Phosphorylation PhosphoSitePlus
T804 Phosphorylation PhosphoSitePlus
S810 Phosphorylation PhosphoSitePlus
T811 Phosphorylation PhosphoSitePlus
S818 Phosphorylation PhosphoSitePlus
S822 Phosphorylation PhosphoSitePlus
S876 Phosphorylation PhosphoSitePlus
S879 Phosphorylation PhosphoSitePlus
T880 Phosphorylation PhosphoSitePlus
K883 Methylation PhosphoSitePlus
K883 Ubiquitination PhosphoSitePlus


O95819 (MAP4K4) as PTM Enzyme



Substrate Site Score Source PMID
P15311 (EZR) T567 PhosphoSitePlus 25799996
P26038 (MSN) T558 PhosphoSitePlus 25799996
P35241 (RDX) T564 PhosphoSitePlus 25799996


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T35 P35 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K54 E54 Biomuta DOID:4159 / skin cancer [ cosmic ]
S134 F134 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K261 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K303 N303 Biomuta DOID:1319 / brain cancer [ icgc ]
Y321 C321 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S324 I324 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S326 I326 Biomuta DOID:3571 / liver cancer [ cosmic ]
R546 M546 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S628 I628 Biomuta DOID:1324 / lung cancer [ cosmic ]
S677 T677 Biomuta DOID:1612 / breast cancer [ cosmic ]
P716 L716 Biomuta DOID:4159 / skin cancer [ cosmic ]
S717 F717 Biomuta DOID:4159 / skin cancer [ cosmic ]
S717 C717 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T743 S743 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S791 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T798 A798 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S800 F800 Biomuta DOID:4159 / skin cancer [ cosmic ]
S801 Y801 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T804 A804 Biomuta DOID:4159 / skin cancer [ icgc ]
T809 M809 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S810 N810 Biomuta DOID:4159 / skin cancer [ cosmic ]
S811 Y811 Biomuta [ cosmic ]
S823 R823 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T828 A828 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S830 F830 Biomuta DOID:4159 / skin cancer [ cosmic ]
S842 F842 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S852 C852 Biomuta DOID:1324 / lung cancer [ cosmic ]
S876 F876 Biomuta DOID:4159 / skin cancer [ cosmic ]
S879 I879 Biomuta DOID:1324 / lung cancer [ cosmic ]
S882 F882 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S882 P882 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S900 L900 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K957 T957 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y992 D992 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1212 E1212 Biomuta DOID:9256 / colorectal cancer [ cosmic ]