iPTMnet Report for O95817 (BAG3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95817 / BAG3_HUMAN
Protein Name BAG family molecular chaperone regulator 3
Gene Name Name: BAG3
Synonyms:BIS;
Organism Homo sapiens (Human)

PRO ID PR:O95817
DAG View
PRO Name BAG family molecular chaperone regulator 3 (human)
Definition A BAG family molecular chaperone regulator 3 that is encoded in the genome of human.
Short Label hBAG3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95817 (BAG3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 20068231
S7 Phosphorylation HPRD   PhosphoSitePlus 20068231
K29 Acetylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
S65 O-Glycosylation GlyGen 32574038
Y86 Phosphorylation PhosphoSitePlus
R90 Methylation PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
R106 Methylation PhosphoSitePlus
Y114 Phosphorylation PhosphoSitePlus
R121 Methylation PhosphoSitePlus
R123 Methylation PhosphoSitePlus
T124 O-Glycosylation GlyGen 23301498, 23271734, 33214551, ...30379171, 32574038, 28657654, 35254053, 31492838, 29485866, 31373491
R133 Methylation PhosphoSitePlus
S134 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S136 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
R139 Methylation PhosphoSitePlus
T144 O-Glycosylation GlyGen 23301498, 23271734, 33214551, ...30379171, 32574038, 28657654, 35254053, 31492838, 29485866, 31373491
T145 O-Glycosylation GlyGen 23301498, 23271734, 33214551, ...30379171, 32574038, 28657654, 35254053, 31492838, 29485866, 31373491
K149 Ubiquitination PhosphoSitePlus
C151 S-Nitrosylation dbSNO 26338901
S165 O-Glycosylation GlyGen 23301498, 23271734, 33214551, ...30379171, 32574038, 28657654, 35254053, 31492838, 29485866, 31373491
S171 O-Glycosylation GlyGen 31373491
S171 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18491316, 17081983, ...18220336, 19664995
S173 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18491316, 23186163, ...18220336, 19664995, 18452278, 18669648, 19415658
S177 O-Glycosylation GlyGen 31373491
S177 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
C179 S-Nitrosylation dbSNO 26338901
S180 O-Glycosylation GlyGen 31373491
S180 Phosphorylation PhosphoSitePlus
S181 O-Glycosylation GlyGen 31373491
S182 O-Glycosylation GlyGen 23301498, 23271734, 33214551, ...30379171, 32574038, 28657654, 35254053, 31492838, 29485866, 31373491
S184 O-Glycosylation GlyGen 31373491
S187 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus   RLIMS-P   Signor 24577090, 23108398
S190 Phosphorylation PhosphoSitePlus
S194 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18220336, 19651622, ...20068231, 17924679
S195 Phosphorylation HPRD   PhosphoSitePlus 20068231
S198 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
R203 Methylation PhosphoSitePlus
Y205 Phosphorylation PhosphoSitePlus
S207 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
R218 Methylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
K230 Methylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
Y233 Phosphorylation PhosphoSitePlus
Y240 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340, 16094384
T242 Phosphorylation PhosphoSitePlus
Y247 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455
K249 Ubiquitination PhosphoSitePlus
R258 Methylation PhosphoSitePlus
R261 Methylation PhosphoSitePlus
S264 Phosphorylation HPRD   PhosphoSitePlus 17322306, 20068231
R267 Methylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus   UniProt 23186163
S274 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18669648, 17081983, ...20068231
S275 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 15302935, ...19651622, 18669648, 20068231
S279 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 15302935, ...19651622, 18669648, 20068231, 18212344
S283 O-Glycosylation GlyGen 31373491
S283 Phosphorylation HPRD   PhosphoSitePlus 17322306, 20068231, 18691976
S284 O-Glycosylation GlyGen 31373491
S284 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648, 20068231
T285 Phosphorylation P42345 (MTOR) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17287340, 17081983, ...18220336, 19651622, 17322306, 18669648, 21659604, 23186163, 20068231, 16964243
S289 Phosphorylation P42345 (MTOR) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17081983, 17287340, ...16964243, 18691976, 18220336, 19664994, 19651622, 17322306, 18669648, 21659604, 23186163, 19415658, 20068231, 18212344
S291 O-Glycosylation GlyGen 32574038, 31373491
S291 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18691976, 23186163, ...16964243, 18220336, 19651622, 18669648, 20068231
S315 O-Glycosylation GlyGen 31373491
S315 Phosphorylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
S377 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18691976, 18491316, ...23186163, 16964243, 15302935, 19651622, 19664995, 17322306, 18669648, 24275569, 19415658, 20068231, 17081983
S381 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648, 17081983, ...19415658
S385 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18691976, 19664995, ...19651622, 18669648, 24275569, 20068231
S386 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18491316, 17081983, ...18669648, 19415658, 20068231
S389 Phosphorylation PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus
T406 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18691976, 23186163, ...18669648, 20068231
K431 Acetylation PhosphoSitePlus
K445 Acetylation PhosphoSitePlus
K445 Sumoylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus
Y457 Phosphorylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
Y508 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K29 N29 Biomuta DOID:363 / uterine cancer [ cosmic ]
R90 * Biomuta DOID:4159 / skin cancer [ cosmic ]
R121 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
R121 Q121 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R123 Q123 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R123 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S134 F134 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S136 L136 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R139 W139 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ]
R139 Q139 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T145 I145 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C151 R151 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S184 F184 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S190 F190 Biomuta DOID:4159 / skin cancer [ cosmic ]
S194 N194 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
R203 W203 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y205 C205 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y240 H240 Biomuta DOID:363 / uterine cancer [ icgc ]
R258 W258 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R261 W261 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R261 Q261 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
R261 L261 Biomuta DOID:2021 / placenta cancer [ cosmic ]
S269 F269 Biomuta DOID:4159 / skin cancer [ cosmic ]
S274 L274 Biomuta DOID:4159 / skin cancer [ cosmic ]
S275 I275 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T285 M285 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S386 F386 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]