Protein Information

Cytoscape View

UniProt AC / UniProt ID O95801 / TTC4_HUMAN
Protein Name Tetratricopeptide repeat protein 4
Gene Name Name: TTC4
Organism Homo sapiens (Human)

PRO ID PR:O95801
DAG View
PRO Name tetratricopeptide repeat protein 4 (human)
Definition A tetratricopeptide repeat protein 4 that is encoded in the genome of human.
Short Label hTTC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O95801 (TTC4) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
S10 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
R27 Methylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus   UniProt 23186163
S51 Phosphorylation PhosphoSitePlus   UniProt 23186163
K80 Ubiquitination PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
Y89 Phosphorylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
Y129 Phosphorylation PhosphoSitePlus
K227 Acetylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
S234 Phosphorylation HPRD   phospho.ELM 18669648
S243 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S245 Phosphorylation HPRD   phospho.ELM 18669648
S267 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
R334 Methylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
C367 S-Nitrosylation dbSNO 19483679
C374 S-Nitrosylation dbSNO 19483679

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R27 L27 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K41 E41 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K41 N41 Biomuta DOID:363 / uterine cancer [ tcga ]
S47 T47 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K227 N227 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S234 L234 Biomuta DOID:4362 / cervical cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
C374 F374 Biomuta DOID:3571 / liver cancer [ icgc ]