Protein Information

Cytoscape View


UniProt AC / UniProt ID O95786 / DDX58_HUMAN
Protein Name Probable ATP-dependent RNA helicase DDX58
Gene Name Name: DDX58
Organism Homo sapiens (Human)

PRO ID PR:O95786
DAG View
PRO Name probable ATP-dependent RNA helicase DDX58 (human)
Definition A probable ATP-dependent RNA helicase DDX58 that is encoded in the genome of human.
Short Label hDDX58
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95786 (DDX58) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation P05771 (PRKCB) , P17252 (PRKCA) neXtProt   PhosphoSitePlus   RLIMS-P 22114345, 20406818
Y40 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K96 Sumoylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PRO   PhosphoSitePlus   UniProt 19484123
K164 Ubiquitination PRO   PhosphoSitePlus   UniProt 19484123
K169 Ubiquitination PhosphoSitePlus
T170 Phosphorylation P17252 (PRKCA) , P05771 (PRKCB) neXtProt   PhosphoSitePlus   RLIMS-P 22114345, 20071582
K172 Ubiquitination PRO   PhosphoSitePlus   UniProt 19484123
K177 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus   UniProt 26471729
K190 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
Y473 Phosphorylation PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
S654 Phosphorylation PhosphoSitePlus
K657 Ubiquitination PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
T667 Phosphorylation PhosphoSitePlus
T671 Phosphorylation PhosphoSitePlus
T674 Phosphorylation PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
K759 Ubiquitination PhosphoSitePlus
S764 Phosphorylation PhosphoSitePlus
T770 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor   UniProt 21068236
K779 Ubiquitination PhosphoSitePlus
K788 Ubiquitination PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
K812 Ubiquitination PhosphoSitePlus
K851 Ubiquitination PhosphoSitePlus
S854 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor   UniProt 21068236
S855 Phosphorylation Q14164 (IKBKE) , P68400 (CSNK2A1) PhosphoSitePlus   Signor   UniProt 21068236, 26354181
K858 Acetylation PhosphoSitePlus   UniProt 19608861
K858 Ubiquitination PhosphoSitePlus
Y879 Phosphorylation PhosphoSitePlus
K880 Ubiquitination PhosphoSitePlus
K888 Sumoylation PhosphoSitePlus
K909 Acetylation PhosphoSitePlus
K909 Ubiquitination PhosphoSitePlus
K915 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047161 (hDDX58/Ubiq:1) ubK154,ubK164,ubK172 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O95786 (DDX58) S8 Q7Z434 (MAVS) unknown eFIP 20406818
Phosphorylation O95786 (DDX58) S8 Q14258 (TRIM25) decreased_association eFIP 20406818
Phosphorylation O95786 (DDX58) T170 Q7Z434 (MAVS) unknown eFIP 20071582