iPTMnet Report for O95782 (AP2A1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95782 / AP2A1_HUMAN
Protein Name AP-2 complex subunit alpha-1
Gene Name Name: AP2A1
Synonyms:ADTAA,CLAPA1;
Organism Homo sapiens (Human)

PRO ID PR:O95782
DAG View
PRO Name AP-2 complex subunit alpha-1 (human)
Definition An AP-2 complex subunit alpha-1 that is encoded in the genome of human.
Short Label hAP2A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95782 (AP2A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
K6 Ubiquitination PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
R21 Methylation PhosphoSitePlus
K35 Acetylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
C129 Methylation IEDB 31844290
K165 Acetylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
T189 O-Glycosylation GlyGen 33214551, 30397120, 34725712, ...33465208, 34019948, 32119511, 28510447, 34229054
T189 Phosphorylation PhosphoSitePlus
C213 Methylation IEDB 31844290
S234 Phosphorylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
Y412 Phosphorylation PhosphoSitePlus
Y418 Phosphorylation PhosphoSitePlus
Y456 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus
R570 Methylation PhosphoSitePlus
S611 O-Glycosylation GlyGen 33214551, 30397120, 34725712, ...33465208, 34019948, 32119511, 28510447, 34229054
S611 Phosphorylation PhosphoSitePlus
K620 Ubiquitination PhosphoSitePlus
S626 Phosphorylation PhosphoSitePlus   UniProt 18691976
S636 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
T647 Phosphorylation PhosphoSitePlus
T650 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S652 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T653 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S655 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S657 Phosphorylation PhosphoSitePlus
K750 Ubiquitination PhosphoSitePlus
K810 Ubiquitination PhosphoSitePlus
T836 Phosphorylation PhosphoSitePlus
K856 Ubiquitination PhosphoSitePlus
T868 Phosphorylation PhosphoSitePlus
K880 Ubiquitination PhosphoSitePlus
K891 Ubiquitination PhosphoSitePlus
K894 Ubiquitination PhosphoSitePlus
K905 Ubiquitination PhosphoSitePlus
K907 Ubiquitination PhosphoSitePlus
C970 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
S517 Phosphorylation HPRD 18691976
S626 Phosphorylation HPRD 18691976
S636 Phosphorylation HPRD 18691976
S637 Phosphorylation HPRD 18691976
S649 Phosphorylation HPRD 18691976
T650 Phosphorylation HPRD 18691976, 18669648
S652 Phosphorylation HPRD 18691976, 18669648, 20068231
T653 Phosphorylation HPRD 18691976, 18669648, 20068231
S655 Phosphorylation HPRD 18691976, 18669648, 20068231, ...18452278
S657 Phosphorylation HPRD 18691976, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S517 Phosphorylation HPRD 18691976
S626 Phosphorylation HPRD 18691976
S636 Phosphorylation HPRD 18691976
S637 Phosphorylation HPRD 18691976
S649 Phosphorylation HPRD 18691976
T650 Phosphorylation HPRD 18691976, 18669648
S652 Phosphorylation HPRD 18691976, 18669648, 20068231
T653 Phosphorylation HPRD 18691976, 18669648, 20068231
S655 Phosphorylation HPRD 18691976, 18669648, 20068231, ...18452278
S657 Phosphorylation HPRD 18691976, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K6 N6 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
R21 W21 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C129 S129 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S179 L179 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
T189 M189 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R570 H570 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R570 C570 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S637 R637 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]