iPTMnet Report for O95757 (HSPA4L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95757 / HS74L_HUMAN
Protein Name Heat shock 70 kDa protein 4L
Gene Name Name: HSPA4L
Synonyms:APG1,OSP94;
Organism Homo sapiens (Human)

PRO ID PR:O95757
DAG View
PRO Name heat shock 70 kDa protein 4L (human)
Definition A heat shock 70 kDa protein 4L that is encoded in the genome of human.
Short Label hHSPA4L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95757 (HSPA4L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus
R33 Methylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus   UniProt 23186163
R86 Methylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K219 Acetylation PhosphoSitePlus
K221 Acetylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
Y230 Phosphorylation HPRD 20068231
K249 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
R265 Methylation PhosphoSitePlus
C270 Methylation IEDB 31844290
K272 Acetylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K274 Acetylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
T365 Phosphorylation PhosphoSitePlus
C376 Methylation IEDB 31844290
S384 Phosphorylation PhosphoSitePlus
K388 Methylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
C417 S-Nitrosylation dbSNO 26338901
C421 S-Nitrosylation dbSNO 26338901
K422 Ubiquitination PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus   UniProt 23186163
T514 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
C540 S-Nitrosylation dbSNO 26338901
T545 Phosphorylation PhosphoSitePlus
T571 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18212344
K573 Ubiquitination PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus   UniProt 23186163
S587 Phosphorylation PhosphoSitePlus
C589 S-Nitrosylation dbSNO 26338901
S599 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y600 Phosphorylation PhosphoSitePlus
K612 Ubiquitination PhosphoSitePlus
K621 Ubiquitination PhosphoSitePlus
Y627 Phosphorylation PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
Y663 Phosphorylation PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
Y684 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y692 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y726 Phosphorylation PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
K739 Ubiquitination PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
T761 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332
S769 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 29351928, 34019948, 32870666, 28510447
K788 Ubiquitination PhosphoSitePlus
S814 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K53 R53 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K221 Q221 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y230 N230 Biomuta DOID:1324 / lung cancer [ cosmic ]
R265 H265 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K275 R275 Biomuta DOID:3571 / liver cancer [ cosmic ]
K360 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K573 T573 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y692 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S769 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S814 I814 Biomuta DOID:9256 / colorectal cancer [ cosmic ]