Protein Information

Cytoscape View

UniProt AC / UniProt ID O95749 / GGPPS_HUMAN
Protein Name Geranylgeranyl pyrophosphate synthase
Gene Name Name: GGPS1
Organism Homo sapiens (Human)

PRO ID PR:O95749
DAG View
PRO Name geranylgeranyl pyrophosphate synthase (human)
Definition A geranylgeranyl pyrophosphate synthase that is encoded in the genome of human.
Short Label hGGPS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O95749 (GGPS1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K3 Ubiquitination PhosphoSitePlus
Y16 Phosphorylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
K25 Acetylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
Y94 Phosphorylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
R278 Methylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 I1 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
Y94 H94 Biomuta DOID:5041 / esophageal cancer [ icgc ]
K265 E265 Biomuta DOID:363 / uterine cancer [ tcga ]
R278 L278 Biomuta DOID:363 / uterine cancer [ tcga ]
R278 C278 Biomuta DOID:10283 / prostate cancer [ cosmic ]