Protein Information

Cytoscape View


UniProt AC / UniProt ID O95747 / OXSR1_HUMAN
Protein Name Serine/threonine-protein kinase OSR1
Gene Name Name: OXSR1
Synonyms:KIAA1101;
Organism Homo sapiens (Human)

PRO ID PR:O95747
DAG View
PRO Name serine/threonine-protein kinase OSR1 (human)
Definition A serine/threonine-protein kinase OSR1 that is encoded in the genome of human.
Short Label hOXSR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95747 (OXSR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22223895
S2 Phosphorylation PhosphoSitePlus
K42 Acetylation PhosphoSitePlus
K46 Acetylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
T185 Phosphorylation Q9H4A3 (WNK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 27400149, 24191005, 16083423, ...17190791
T189 Phosphorylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
R287 Methylation PhosphoSitePlus
K297 Methylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
T310 Phosphorylation PhosphoSitePlus   UniProt 23186163
S312 Phosphorylation PhosphoSitePlus
S324 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S325 Phosphorylation Q9H4A3 (WNK1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 16083423, 17190791, ...19651622, 27400149, 24191005
T331 Phosphorylation HPRD   PhosphoSitePlus 20058876
S339 Phosphorylation P42345 (MTOR) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 21406692, 23186163, ...17081983, 19664994, 20058876, 18452278, 19651622, 15302935, 18669648, 19690332, 24275569, 20166139, 24191005, 18318008, 15345747, 19415658, 20068231
S347 Phosphorylation PhosphoSitePlus   UniProt 19690332
S355 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus   UniProt 23186163
S369 Phosphorylation PhosphoSitePlus
S425 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S427 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17525332, 18669648, ...20068231, 20068230
T430 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
K444 Methylation PhosphoSitePlus
R451 Methylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus


O95747 (OXSR1) as PTM Enzyme



Substrate Site Score Source PMID
P55011 (SLC12A2) T203 HPRD   PhosphoSitePlus   Signor 16669787, 21423148, 12145304
P55011-1 (SLC12A2) T207 HPRD   PhosphoSitePlus   Signor 16669787, 21423148
P55011 (SLC12A2) T212 HPRD   PhosphoSitePlus   Signor 16669787, 21423148, 12145304
P55011 (SLC12A2) T217 PhosphoSitePlus 21423148
P55011 (SLC12A2) T230 PhosphoSitePlus 21423148
P55017 (SLC12A3) T46 PhosphoSitePlus 18270262, 21423148
P55017 (SLC12A3) T55 PhosphoSitePlus 18270262, 21423148
P55017 (SLC12A3) T60 PhosphoSitePlus   Signor 18270262, 21423148
P55017 (SLC12A3) S73 PhosphoSitePlus 21423148
Q13153-1 (PAK1) T84 HPRD   neXtProt   Signor 14707132
Q13621 (SLC12A1) T95 PhosphoSitePlus 21423148, 21321328
Q13621 (SLC12A1) T100 PhosphoSitePlus 21423148, 21321328
Q13621 (SLC12A1) T105 PhosphoSitePlus 21321328
Q13621 (SLC12A1) T118 PhosphoSitePlus 21423148
Q13621 (SLC12A1) S120 PhosphoSitePlus 21423148


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K110 E110 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T189 P189 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S263 L263 Biomuta DOID:1909 / melanoma [ tcga ]
S269 L269 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R287 S287 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S312 Y312 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S324 F324 Biomuta DOID:1909 / melanoma [ tcga ]
S355 L355 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R451 Q451 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ]
R451 * Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ tcga ] DOID:1909 / melanoma [ icgc, tcga ]