iPTMnet Report for O95714 (HERC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95714 / HERC2_HUMAN
Protein Name E3 ubiquitin-protein ligase HERC2
Gene Name Name: HERC2
Organism Homo sapiens (Human)

PRO ID PR:O95714
DAG View
PRO Name E3 ubiquitin-protein ligase HERC2 (human)
Definition An E3 ubiquitin-protein ligase HERC2 that is encoded in the genome of human.
Short Label hHERC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95714 (HERC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K17 Ubiquitination PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
T272 Phosphorylation PhosphoSitePlus   UniProt 23186163
K276 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
T647 Phosphorylation PhosphoSitePlus   UniProt 21406692
K653 Ubiquitination PhosphoSitePlus
K661 Ubiquitination PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
K709 Ubiquitination PhosphoSitePlus
T748 Phosphorylation PhosphoSitePlus
K967 Methylation PhosphoSitePlus
K969 Methylation PhosphoSitePlus
K969 Ubiquitination PhosphoSitePlus
T986 Phosphorylation PhosphoSitePlus
K990 Ubiquitination PhosphoSitePlus
S1021 Phosphorylation PhosphoSitePlus
T1023 Phosphorylation PhosphoSitePlus
K1220 Ubiquitination PhosphoSitePlus
K1231 Ubiquitination PhosphoSitePlus
S1366 Phosphorylation PhosphoSitePlus
T1370 Phosphorylation PhosphoSitePlus
K1374 Ubiquitination PhosphoSitePlus
K1469 Ubiquitination PhosphoSitePlus
T1472 Phosphorylation PhosphoSitePlus
K1488 Ubiquitination PhosphoSitePlus
K1493 Ubiquitination PhosphoSitePlus
K1503 Ubiquitination PhosphoSitePlus
S1539 Phosphorylation PhosphoSitePlus
S1577 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1588 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K1594 Ubiquitination PhosphoSitePlus
K1600 Ubiquitination PhosphoSitePlus
S1601 Phosphorylation PhosphoSitePlus
K1605 Ubiquitination PhosphoSitePlus
S1633 Phosphorylation PhosphoSitePlus
K1645 Ubiquitination PhosphoSitePlus
K1660 Ubiquitination PhosphoSitePlus
K1677 Ubiquitination PhosphoSitePlus
S1791 Phosphorylation PhosphoSitePlus
T1814 Phosphorylation PhosphoSitePlus
S1835 Phosphorylation PhosphoSitePlus
T1851 O-Glycosylation GlyGen 30379171, 29351928
S1938 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648
S1942 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648, 17081983, ...19651622
T1944 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 18669648
S1948 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983
S2003 Phosphorylation PhosphoSitePlus
K2008 Ubiquitination PhosphoSitePlus
S2011 Phosphorylation PhosphoSitePlus
K2304 Ubiquitination PhosphoSitePlus
K2338 Ubiquitination PhosphoSitePlus
S2454 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 19651622, ...19690332, 20068231
K2657 Ubiquitination PhosphoSitePlus
T2662 Phosphorylation PhosphoSitePlus
S2772 Phosphorylation PhosphoSitePlus
S2788 Phosphorylation PhosphoSitePlus
N2790 N-Glycosylation GlyGen 29671580
K2817 Ubiquitination PhosphoSitePlus
K2893 Ubiquitination PhosphoSitePlus
S2928 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 18491316, ...23186163, 17081983, 19651622, 17322306, 18669648, 20068231
S2942 Phosphorylation HPRD   phospho.ELM 18669648
K2947 Ubiquitination PhosphoSitePlus
S2953 Phosphorylation PhosphoSitePlus
T2956 Phosphorylation PhosphoSitePlus
K2969 Ubiquitination PhosphoSitePlus
K2976 Ubiquitination PhosphoSitePlus
S2978 Phosphorylation PhosphoSitePlus
K3067 Ubiquitination PhosphoSitePlus
K3078 Ubiquitination PhosphoSitePlus
K3097 Ubiquitination PhosphoSitePlus
K3141 Ubiquitination PhosphoSitePlus
K3146 Ubiquitination PhosphoSitePlus
S3241 Phosphorylation PhosphoSitePlus
K3247 Ubiquitination PhosphoSitePlus
K3299 Ubiquitination PhosphoSitePlus
K3366 Ubiquitination PhosphoSitePlus
K3374 Ubiquitination PhosphoSitePlus
K3382 Ubiquitination PhosphoSitePlus
S3386 Phosphorylation PhosphoSitePlus
S3462 Phosphorylation PhosphoSitePlus
K3469 Ubiquitination PhosphoSitePlus
S3475 O-Glycosylation GlyGen 30379171, 29351928
T3480 Phosphorylation PhosphoSitePlus
T3485 Phosphorylation PhosphoSitePlus
S3487 O-Glycosylation GlyGen 30379171, 29351928
S3492 Phosphorylation PhosphoSitePlus
K3554 Ubiquitination PhosphoSitePlus
S3647 Phosphorylation PhosphoSitePlus
S3674 Phosphorylation PhosphoSitePlus
S3677 Phosphorylation PhosphoSitePlus
S3678 Phosphorylation PhosphoSitePlus
K3688 Ubiquitination PhosphoSitePlus
K3690 Ubiquitination PhosphoSitePlus
N3746 N-Glycosylation GlyGen 29741879
S3764 Phosphorylation PhosphoSitePlus
S3769 Phosphorylation PhosphoSitePlus
K3780 Ubiquitination PhosphoSitePlus
K3839 Ubiquitination PhosphoSitePlus
K4133 Ubiquitination PhosphoSitePlus
S4182 O-Glycosylation GlyGen 30379171, 29351928
T4195 Phosphorylation PhosphoSitePlus
K4249 Acetylation PhosphoSitePlus
C4308 Methylation IEDB 31844290
K4396 Ubiquitination PhosphoSitePlus
K4402 Ubiquitination PhosphoSitePlus
K4431 Ubiquitination PhosphoSitePlus
K4441 Ubiquitination PhosphoSitePlus
S4458 Phosphorylation PhosphoSitePlus
S4566 Phosphorylation PhosphoSitePlus
T4568 Phosphorylation PhosphoSitePlus
Y4585 Phosphorylation PhosphoSitePlus
S4687 Phosphorylation HPRD 20068231
T4690 Phosphorylation HPRD 20068231
S4710 Phosphorylation HPRD 20068231
K4774 Ubiquitination PhosphoSitePlus
K4780 Ubiquitination PhosphoSitePlus
Y4796 Phosphorylation PhosphoSitePlus
S4810 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S4811 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S4814 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
T4827 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22508508, 20023648
Site PTM Type PTM Enzyme Score Source PMID
N2790 N-Glycosylation PRO 29671580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K72 N72 Biomuta DOID:4159 / skin cancer [ cosmic ]
K72 M72 Biomuta DOID:263 / kidney cancer [ cosmic ]
S263 F263 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T272 M272 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K276 I276 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T405 M405 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T1472 R1472 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1539 Y1539 Biomuta DOID:1324 / lung cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1633 F1633 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K1660 R1660 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1791 C1791 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1942 L1942 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
K2008 T2008 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
K2304 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K2304 T2304 Biomuta DOID:363 / uterine cancer [ icgc ]
S2454 L2454 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T2662 I2662 Biomuta DOID:1319 / brain cancer [ cosmic ]
N2790 D2790 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2893 E2893 Biomuta DOID:363 / uterine cancer [ icgc ]
S2928 L2928 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S2953 L2953 Biomuta DOID:1324 / lung cancer [ cosmic ]
T2956 M2956 Biomuta DOID:263 / kidney cancer [ icgc ]
K2976 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S2978 F2978 Biomuta DOID:4159 / skin cancer [ cosmic ]
K3078 N3078 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K3146 E3146 Biomuta DOID:3571 / liver cancer [ cosmic ]
K3366 T3366 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K3382 N3382 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S3386 P3386 Biomuta DOID:1319 / brain cancer [ cosmic ]
T3485 I3485 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S3487 L3487 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S3769 G3769 Biomuta DOID:10534 / stomach cancer [ cosmic ]
C4308 R4308 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K4402 N4402 Biomuta DOID:263 / kidney cancer [ cosmic ]
T4568 I4568 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S4687 L4687 Biomuta DOID:363 / uterine cancer [ icgc ]
S4687 A4687 Biomuta DOID:9256 / colorectal cancer [ cosmic ]