Protein Information

Cytoscape View


UniProt AC / UniProt ID O95678 / K2C75_HUMAN
Protein Name Keratin, type II cytoskeletal 75
Gene Name Name: KRT75
Synonyms:K6HF,KB18;
Organism Homo sapiens (Human)

PRO ID PR:O95678
DAG View
PRO Name keratin, type II cytoskeletal 75 (human)
Definition A keratin, type II cytoskeletal 75 that is encoded in the genome of human.
Short Label hKRT75
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95678 (KRT75) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
T8 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
R15 Methylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
R29 Methylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
T155 Phosphorylation PhosphoSitePlus
K159 Acetylation PhosphoSitePlus
K159 Methylation PhosphoSitePlus
K159 Sumoylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
S162 Phosphorylation HPRD   PhosphoSitePlus 18669648
K166 Acetylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
Y264 Phosphorylation PhosphoSitePlus
T297 Phosphorylation PhosphoSitePlus
T302 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
Y327 Phosphorylation PhosphoSitePlus
S334 Phosphorylation HPRD   PhosphoSitePlus 18767875, 17081983
Y342 Phosphorylation PhosphoSitePlus
T344 Phosphorylation PhosphoSitePlus
Y346 Phosphorylation PhosphoSitePlus
T352 Phosphorylation PhosphoSitePlus
S383 Phosphorylation HPRD   PhosphoSitePlus 20068231
K407 Ubiquitination PhosphoSitePlus
K424 Sumoylation PhosphoSitePlus
Y434 Phosphorylation PhosphoSitePlus
K453 Acetylation PhosphoSitePlus
R461 Methylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 F11 Biomuta DOID:363 / uterine cancer [ tcga ]
R29 H29 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S72 F72 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T302 K302 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S334 N334 Biomuta DOID:1324 / lung cancer [ cosmic ]
T344 S344 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
T344 I344 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y346 * Biomuta DOID:3571 / liver cancer [ icgc ]