iPTMnet Report for O95671 (ASMTL)
Protein Information
UniProt AC / UniProt ID | O95671 / ASML_HUMAN |
Protein Name | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein |
Gene Name | Name: ASMTL |
Organism | Homo sapiens (Human) |
PRO ID | PR:O95671 |
PRO Name | probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (human) |
Definition | A probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein that is encoded in the genome of human. |
Short Label | hASMTL |
Category | organism-gene |
O95671 (ASMTL) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
C4 | Methylation | score1 | IEDB | 31844290 | ||
S21 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 24275569 | ||
K48 | Ubiquitination | score1 | PhosphoSitePlus | |||
T53 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y55 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y57 | Phosphorylation | score1 | PhosphoSitePlus | |||
T61 | Phosphorylation | score1 | PhosphoSitePlus | |||
K63 | Ubiquitination | score1 | PhosphoSitePlus | |||
K65 | Ubiquitination | score1 | PhosphoSitePlus | |||
R72 | Methylation | score1 | PhosphoSitePlus | |||
Y74 | Phosphorylation | score1 | PhosphoSitePlus | |||
K76 | Ubiquitination | score1 | PhosphoSitePlus | |||
K100 | Ubiquitination | score1 | PhosphoSitePlus | |||
K104 | Ubiquitination | score1 | PhosphoSitePlus | |||
K149 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y212 | Phosphorylation | score1 | PhosphoSitePlus | |||
S223 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
K225 | Ubiquitination | score1 | PhosphoSitePlus | |||
S228 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 24275569 | ||
T234 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 24275569 | ||
S239 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 21406692, 23186163, ... | ||
T249 | Phosphorylation | score1 | PhosphoSitePlus | |||
S255 | Phosphorylation | score1 | PhosphoSitePlus | |||
C274 | S-Nitrosylation | score0 | dbSNO | 22178444 | ||
K299 | Ubiquitination | score1 | PhosphoSitePlus | |||
K306 | Ubiquitination | score1 | PhosphoSitePlus | |||
K308 | Ubiquitination | score1 | PhosphoSitePlus | |||
K314 | Ubiquitination | score1 | PhosphoSitePlus | |||
K320 | Ubiquitination | score1 | PhosphoSitePlus | |||
K327 | Ubiquitination | score1 | PhosphoSitePlus | |||
K409 | Ubiquitination | score1 | PhosphoSitePlus | |||
S421 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K437 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y473 | Phosphorylation | score1 | PhosphoSitePlus | |||
S517 | Phosphorylation | score1 | PhosphoSitePlus | |||
K537 | Ubiquitination | score1 | PhosphoSitePlus | |||
K547 | Ubiquitination | score1 | PhosphoSitePlus | |||
T557 | Phosphorylation | score1 | PhosphoSitePlus | |||
K563 | Ubiquitination | score1 | PhosphoSitePlus | |||
S573 | Phosphorylation | score1 | PhosphoSitePlus | |||
T580 | Phosphorylation | score1 | PhosphoSitePlus | |||
K583 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S21 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 19664994 | ||
S223 | Phosphorylation | score0 | HPRD | 18669648 | ||
S228 | Phosphorylation | score0 | HPRD | 20166139, 18691976, 18669648 | ||
T234 | Phosphorylation | score0 | HPRD | 20166139, 18669648 | ||
S239 | Phosphorylation | score0 | HPRD | 18691976, 17081983, 19651622, ... | ||
T424 | Phosphorylation | score0 | HPRD | 20068231 | ||
S517 | Phosphorylation | score0 | HPRD | 20068231 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T76 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
C4 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
C4 | F4 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
Y57 | H57 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R72 | W72 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
R72 | Q72 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ] | |
T76 | I76 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
S228 | P228 | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] | |
S255 | R255 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
S255 | N255 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
K308 | N308 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
Y473 | C473 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T557 | K557 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
K563 | T563 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] |