iPTMnet Report for O95671 (ASMTL)
Protein Information
| UniProt AC / UniProt ID | O95671 / ASML_HUMAN |
| Protein Name | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein |
| Gene Name | Name: ASMTL |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O95671 |
| PRO Name | probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (human) |
| Definition | A probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein that is encoded in the genome of human. |
| Short Label | hASMTL |
| Category | organism-gene |
O95671 (ASMTL) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| C4 | Methylation | score1 | IEDB | 31844290 | ||
| S21 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 24275569 | ||
| K48 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T53 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y55 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y57 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T61 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K63 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K65 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R72 | Methylation | score1 | PhosphoSitePlus | |||
| Y74 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K76 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K100 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K104 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K149 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y212 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S223 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| K225 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S228 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 24275569 | ||
| T234 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 24275569 | ||
| S239 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 21406692, 23186163, ... | ||
| T249 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S255 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C274 | S-Nitrosylation | score0 | dbSNO | 22178444 | ||
| K299 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K306 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K308 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K314 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K320 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K327 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K409 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S421 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K437 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y473 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S517 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K537 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K547 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T557 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K563 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S573 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T580 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K583 | Ubiquitination | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S21 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 19664994 | ||
| S223 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S228 | Phosphorylation | score0 | HPRD | 20166139, 18691976, 18669648 | ||
| T234 | Phosphorylation | score0 | HPRD | 20166139, 18669648 | ||
| S239 | Phosphorylation | score0 | HPRD | 18691976, 17081983, 19651622, ... | ||
| T424 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S517 | Phosphorylation | score0 | HPRD | 20068231 |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T76 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| C4 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| C4 | F4 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| Y57 | H57 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| R72 | W72 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| R72 | Q72 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ] | |
| T76 | I76 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| S228 | P228 | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] | |
| S255 | R255 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S255 | N255 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| K308 | N308 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| Y473 | C473 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T557 | K557 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| K563 | T563 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] |
DAG View