iPTMnet Report for O95644 (NFATC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95644 / NFAC1_HUMAN
Protein Name Nuclear factor of activated T-cells, cytoplasmic 1
Gene Name Name: NFATC1
Synonyms:NFAT2,NFATC;
Organism Homo sapiens (Human)

PRO ID PR:O95644
DAG View
PRO Name nuclear factor of activated T-cells, cytoplasmic 1 (human)
Definition A nuclear factor of activated T-cells, cytoplasmic 1 that is encoded in the genome of human.
Short Label hNFATC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95644 (NFATC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R23 Methylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
S172 Phosphorylation P27361 (MAPK3) , Q16539 (MAPK14) , P45983 (MAPK8) , P53779 (MAPK10) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 24863062, 10652349
S175 Phosphorylation PRO
S176 Phosphorylation PRO
S178 Phosphorylation PRO
S179 Phosphorylation PRO
S181 Phosphorylation PRO
S184 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
Y197 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S233 Phosphorylation PRO   PhosphoSitePlus   UniProt 23186163
S237 Phosphorylation PRO   PhosphoSitePlus
S241 Phosphorylation PRO   PhosphoSitePlus
S245 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9072970, 12351631
S250 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PRO   PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus   RLIMS-P 28235034
S269 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9072970, 12351631
S278 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P 28235034
S282 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PRO
S290 Phosphorylation PRO   PhosphoSitePlus
S294 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12351631
S324 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
T339 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
K349 Sumoylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
Y371 Phosphorylation P52333 (JAK3) PhosphoSitePlus 23263556
K379 Ubiquitination PhosphoSitePlus
Y386 Phosphorylation PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus   RLIMS-P 28235034
S409 Phosphorylation PhosphoSitePlus   RLIMS-P 28235034
Y426 Phosphorylation PhosphoSitePlus
T504 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
K612 Acetylation PhosphoSitePlus
K626 Acetylation PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
K702 Sumoylation PhosphoSitePlus
Y709 Phosphorylation PhosphoSitePlus
S765 Phosphorylation PhosphoSitePlus
S772 Phosphorylation PhosphoSitePlus
S813 Phosphorylation PhosphoSitePlus
S887 Phosphorylation PhosphoSitePlus
S903 Phosphorylation PhosphoSitePlus
T912 Phosphorylation PhosphoSitePlus
K914 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S117 Phosphorylation PRO 10866678
S172 Phosphorylation PRO 10866678
Site PTM Type PTM Enzyme Score Source PMID
S233 Phosphorylation HPRD 19664994
S245 Phosphorylation P17252 (PRKCA) HPRD 9072970
S269 Phosphorylation P17252 (PRKCA) HPRD 9072970
S294 Phosphorylation P17252 (PRKCA) HPRD 12351631
Site PTM Type PTM Enzyme Score Source PMID
S233 Phosphorylation HPRD 19664994
S245 Phosphorylation P17252 (PRKCA) HPRD 9072970
S269 Phosphorylation P17252 (PRKCA) HPRD 9072970
S294 Phosphorylation P17252 (PRKCA) HPRD 12351631
Site PTM Type PTM Enzyme Score Source PMID
S220 Phosphorylation HPRD 19664994
S232 Phosphorylation P17252 (PRKCA) HPRD 9072970
S256 Phosphorylation P17252 (PRKCA) HPRD 9072970
S281 Phosphorylation P17252 (PRKCA) HPRD 12351631
Site PTM Type PTM Enzyme Score Source PMID
S220 Phosphorylation HPRD 19664994
S232 Phosphorylation P17252 (PRKCA) HPRD 9072970
S256 Phosphorylation P17252 (PRKCA) HPRD 9072970
S281 Phosphorylation P17252 (PRKCA) HPRD 12351631


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048588 (hNFATC1/Phos:2) pS175,pS176,pS178,pS179,pS181,pS233,pS237,pS241,pS257,pS278,pS286,pS290 PRO
PR:000048589 (hNFATC1/Phos:3) pS257 PRO
PR:000036638 (hNFATC1/iso:1/Phos:1) pS117,pS172 PRO 10866678


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036638 (hNFATC1/iso:1/Phos:1) Interaction PR:O14980 (hXPO1) PRO 10866678
PR:O95644-1 (hNFATC1/iso:C-alpha) increased Interaction PR:O14980 (hXPO1) PRO 10866678
PR:O95644-1 (hNFATC1/iso:C-alpha) Interaction PR:P45983 (hMAPK8) PRO 10866678


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S151 C151 Biomuta DOID:3571 / liver cancer [ cosmic ]
S151 P151 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S153 F153 Biomuta DOID:263 / kidney cancer [ cosmic ]
T154 M154 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S158 R158 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
S169 W169 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S172 T172 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S172 G172 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S181 N181 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S187 A187 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S211 A211 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S220 A220 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S220 F220 Biomuta DOID:9256 / colorectal cancer [ cosmic, cosmic, cosmic ]
S233 A233 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S233 F233 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S237 A237 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S237 P237 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
S256 F256 Biomuta DOID:4159 / skin cancer [ cosmic ]
S257 F257 Biomuta [ cosmic ]
S278 A278 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S282 A282 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S286 P286 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S286 A286 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S290 A290 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S290 F290 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S345 L345 Biomuta DOID:5041 / esophageal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S409 R409 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S670 N670 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S813 L813 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, cosmic, cosmic, cosmic ]