iPTMnet Report for O95639 (CPSF4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95639 / CPSF4_HUMAN
Protein Name Cleavage and polyadenylation specificity factor subunit 4
Gene Name Name: CPSF4
Synonyms:CPSF30,NAR,NEB1;
Organism Homo sapiens (Human)

PRO ID PR:O95639
DAG View
PRO Name cleavage and polyadenylation specificity factor subunit 4 (human)
Definition A cleavage and polyadenylation specificity factor subunit 4 that is encoded in the genome of human.
Short Label hCPSF4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95639 (CPSF4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
K46 Methylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K51 Methylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
Y97 Phosphorylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K133 Acetylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus   UniProt 23186163
S201 Phosphorylation PhosphoSitePlus
S202 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S208 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S212 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...19690332
S231 Phosphorylation PhosphoSitePlus
C245 Methylation IEDB 31844290
S267 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 20068231
S200 Phosphorylation HPRD 19413330
S202 Phosphorylation HPRD 19413330, 18669648, 20058876, ...19664995, 20068231
S212 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664995
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 20068231
T193 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K46 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S61 I61 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
Y97 H97 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K120 Q120 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K122 N122 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T193 A193 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T193 I193 Biomuta DOID:363 / uterine cancer [ icgc ]
S200 L200 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S231 N231 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]