iPTMnet Report for O95628 (CNOT4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95628 / CNOT4_HUMAN
Protein Name CCR4-NOT transcription complex subunit 4
Gene Name Name: CNOT4
Synonyms:NOT4;
Organism Homo sapiens (Human)

PRO ID PR:O95628
DAG View
PRO Name CCR4-NOT transcription complex subunit 4 (human)
Definition A CCR4-NOT transcription complex subunit 4 that is encoded in the genome of human.
Short Label hCNOT4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95628 (CNOT4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S4 Phosphorylation PhosphoSitePlus
S71 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
Y131 Phosphorylation PhosphoSitePlus
C175 Methylation IEDB 31844290
T192 Phosphorylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
T299 Phosphorylation PhosphoSitePlus
S301 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 23186163
S309 O-Glycosylation GlyGen 34846842, 33214551, 30379171, ...32574038, 34019948, 28657654, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 31373491, 29237092, 30059200
S316 O-Glycosylation GlyGen 33214551, 35254053, 30379171, ...32574038, 32938750, 34019948, 28657654, 30059200, 35132862, 31492838, 29351928, 35289036, 30620550, 31373491, 29237092
S317 O-Glycosylation GlyGen 33214551, 30379171, 32574038, ...34019948, 28657654, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 31373491, 29237092, 30059200
S317 Phosphorylation PhosphoSitePlus
S318 O-Glycosylation GlyGen 33214551, 30379171, 32574038, ...34019948, 28657654, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 31373491, 29237092, 30059200
S321 O-Glycosylation GlyGen 33214551, 30379171, 32574038, ...34019948, 28657654, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 31373491, 29237092, 30059200
S324 O-Glycosylation GlyGen 33214551, 30379171, 32574038, ...34019948, 28657654, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 31373491, 29237092, 30059200
S324 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
T331 O-Glycosylation GlyGen 33214551, 30379171, 32574038, ...34019948, 28657654, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 31373491, 29237092, 30059200
S335 O-Glycosylation GlyGen 31373491
T375 O-Glycosylation GlyGen 33214551, 30379171, 32574038, ...34019948, 28657654, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 31373491, 29237092, 30059200
S396 O-Glycosylation GlyGen 33214551, 30379171, 32574038, ...34019948, 28657654, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 31373491, 29237092, 30059200
K413 Ubiquitination PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
S432 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T434 Phosphorylation PhosphoSitePlus
S435 O-Glycosylation GlyGen 33214551, 30379171, 32574038, ...34019948, 28657654, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 31373491, 29237092, 30059200
S435 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
T443 Phosphorylation PhosphoSitePlus
R475 Methylation IEDB   PhosphoSitePlus   UniProt 24129315, 32357974
R483 Methylation PhosphoSitePlus   UniProt 24129315
Y486 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus   UniProt 19690332
R497 Methylation PhosphoSitePlus   UniProt 24129315
R505 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S71 Phosphorylation HPRD 17525332, 18077418
S258 Phosphorylation PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
S306 Phosphorylation HPRD 20068231
S318 Phosphorylation HPRD 20068231
S321 Phosphorylation HPRD 18669648, 20068231
T328 Phosphorylation HPRD 19651622
S429 Phosphorylation HPRD 19651622, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
R597 Methylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus
T629 Phosphorylation PhosphoSitePlus
R641 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S71 Phosphorylation HPRD 17525332, 18077418
S306 Phosphorylation HPRD 20068231
S318 Phosphorylation HPRD 20068231
S321 Phosphorylation HPRD 18669648, 20068231
T328 Phosphorylation HPRD 19651622
S429 Phosphorylation HPRD 19651622, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 C4 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T192 A192 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S258 P258 Biomuta DOID:363 / uterine cancer [ icgc ]
S298 L298 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T299 M299 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S301 L301 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S306 C306 Biomuta DOID:1324 / lung cancer [ cosmic ]
S309 C309 Biomuta DOID:1324 / lung cancer [ cosmic ]
S318 C318 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S318 I318 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S321 C321 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S321 I321 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S335 L335 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
T375 A375 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T434 K434 Biomuta DOID:3571 / liver cancer [ cosmic ]
S435 C435 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R483 Q483 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S488 L488 Biomuta DOID:4159 / skin cancer [ cosmic ]
S490 R490 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S490 G490 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R497 H497 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R505 H505 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic ]
R641 C641 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, cosmic, cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]