iPTMnet Report for O95602 (POLR1A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95602 / RPA1_HUMAN
Protein Name DNA-directed RNA polymerase I subunit RPA1
Gene Name Name: POLR1A
Organism Homo sapiens (Human)

PRO ID PR:O95602
DAG View
PRO Name DNA-directed RNA polymerase I subunit RPA1 (human)
Definition A DNA-directed RNA polymerase I subunit RPA1 that is encoded in the genome of human.
Short Label hPOLR1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95602 (POLR1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Acetylation PhosphoSitePlus
K5 Methylation PhosphoSitePlus
K5 Ubiquitination PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
C122 Methylation IEDB 31844290
S176 Phosphorylation HPRD   PhosphoSitePlus 20068231
K190 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus   UniProt 23186163
K252 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
T357 Phosphorylation HPRD   PhosphoSitePlus 20068231
T359 Phosphorylation PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
K664 Ubiquitination PhosphoSitePlus
K669 Ubiquitination PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
C780 Methylation IEDB 31844290
K805 Ubiquitination PhosphoSitePlus
Y839 Phosphorylation PhosphoSitePlus
K845 Ubiquitination PhosphoSitePlus
K853 Acetylation PhosphoSitePlus
K853 Ubiquitination PhosphoSitePlus
K864 Ubiquitination PhosphoSitePlus
K866 Acetylation PhosphoSitePlus
K866 Ubiquitination PhosphoSitePlus
K878 Ubiquitination PhosphoSitePlus
K933 Ubiquitination PhosphoSitePlus
S934 Phosphorylation PhosphoSitePlus
C937 Methylation IEDB 31844290
Y941 Phosphorylation PhosphoSitePlus
K960 Ubiquitination PhosphoSitePlus
K981 Ubiquitination PhosphoSitePlus
K1028 Ubiquitination PhosphoSitePlus
S1042 Phosphorylation PhosphoSitePlus
K1049 Methylation PhosphoSitePlus
S1058 Phosphorylation PhosphoSitePlus
K1063 Ubiquitination PhosphoSitePlus
K1078 Ubiquitination PhosphoSitePlus
S1091 Phosphorylation PhosphoSitePlus
Y1092 Phosphorylation PhosphoSitePlus
S1093 Phosphorylation PhosphoSitePlus
K1095 Ubiquitination PhosphoSitePlus
K1101 Ubiquitination PhosphoSitePlus
K1104 Ubiquitination PhosphoSitePlus
Y1125 Phosphorylation PhosphoSitePlus
C1142 Methylation IEDB 31844290
K1180 Ubiquitination PhosphoSitePlus
K1184 Ubiquitination PhosphoSitePlus
S1185 Phosphorylation PhosphoSitePlus
R1191 Methylation PhosphoSitePlus
K1199 Ubiquitination PhosphoSitePlus
S1256 Phosphorylation PhosphoSitePlus
K1311 Ubiquitination PhosphoSitePlus
K1331 Ubiquitination PhosphoSitePlus
K1348 Acetylation PhosphoSitePlus
K1360 Ubiquitination PhosphoSitePlus
T1373 Phosphorylation PhosphoSitePlus
S1386 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648
S1413 Phosphorylation PhosphoSitePlus
S1429 Phosphorylation HPRD   PhosphoSitePlus 19691289, 20068231, 18452278
K1485 Ubiquitination PhosphoSitePlus
T1487 Phosphorylation PhosphoSitePlus
S1489 Phosphorylation PhosphoSitePlus
S1546 Phosphorylation PhosphoSitePlus
Y1554 Phosphorylation HPRD   PhosphoSitePlus 20068231
C1562 Methylation IEDB 31844290
K1571 Ubiquitination PhosphoSitePlus
K1574 Ubiquitination PhosphoSitePlus
T1580 Phosphorylation PhosphoSitePlus
S1695 Phosphorylation PhosphoSitePlus
K1704 Ubiquitination PhosphoSitePlus
R1707 Methylation PhosphoSitePlus
K1716 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S240 F240 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K669 R669 Biomuta DOID:1324 / lung cancer [ cosmic ]
K669 T669 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K718 N718 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
C780 W780 Biomuta DOID:1612 / breast cancer [ cosmic ]
C780 F780 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K878 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
R1191 M1191 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1256 R1256 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1413 C1413 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1429 R1429 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1546 Y1546 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1554 C1554 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1704 N1704 Biomuta DOID:9256 / colorectal cancer [ cosmic ]