iPTMnet Report for O95573 (ACSL3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95573 / ACSL3_HUMAN
Protein Name Fatty acid CoA ligase Acsl3
Gene Name Name: ACSL3
Synonyms:ACS3,FACL3,LACS3;
Organism Homo sapiens (Human)

PRO ID PR:O95573
DAG View
PRO Name fatty acid CoA ligase Acsl3 (human)
Definition A fatty acid CoA ligase Acsl3 that is encoded in the genome of human.
Short Label hACSL3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95573 (ACSL3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
C85 Methylation IEDB 31844290
K90 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
T107 Phosphorylation HPRD   PhosphoSitePlus 20068231
K122 Acetylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
C166 S-Nitrosylation dbSNO 26338901
K220 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
Y351 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
C450 S-Nitrosylation dbSNO 22178444, 19366988, 18335467
C466 Methylation IEDB 31844290
K507 Ubiquitination PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
Y516 Phosphorylation PhosphoSitePlus
K521 Acetylation PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
C561 S-Nitrosylation dbSNO 19483679
C573 Methylation IEDB 31844290
C573 S-Nitrosylation dbSNO 19483679
K575 Ubiquitination PhosphoSitePlus
Y591 Phosphorylation PhosphoSitePlus
S593 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935
K596 Ubiquitination PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
K673 Acetylation PhosphoSitePlus
K673 Ubiquitination PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
S683 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
T688 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648
T691 Phosphorylation PhosphoSitePlus
T695 Phosphorylation PhosphoSitePlus
K699 Acetylation PhosphoSitePlus
K699 Ubiquitination PhosphoSitePlus
K706 Acetylation PhosphoSitePlus
K706 Ubiquitination PhosphoSitePlus
Y709 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K96 T96 Biomuta DOID:363 / uterine cancer [ icgc ]
K122 Q122 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K122 N122 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K220 Q220 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K220 E220 Biomuta DOID:4159 / skin cancer [ cosmic ]
K220 N220 Biomuta DOID:1324 / lung cancer [ cosmic ]
S353 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S353 L353 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K363 Q363 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K363 E363 Biomuta DOID:363 / uterine cancer [ icgc ]
K547 T547 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K575 N575 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y591 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K673 R673 Biomuta DOID:4159 / skin cancer [ cosmic ]
K706 R706 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]