iPTMnet Report for O95551 (TDP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95551 / TYDP2_HUMAN
Protein Name Tyrosyl-DNA phosphodiesterase 2
Gene Name Name: TDP2
Synonyms:EAP2;ORFNames:AD-022;
Organism Homo sapiens (Human)

PRO ID PR:O95551
DAG View
PRO Name tyrosyl-DNA phosphodiesterase 2 (human)
Definition A tyrosyl-DNA phosphodiesterase 2 that is encoded in the genome of human.
Short Label hTDP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95551 (TDP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 22223895
K23 Ubiquitination PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus   RLIMS-P 26701725
S60 Phosphorylation Q16659 (MAPK6) PhosphoSitePlus 26701725
Y61 Phosphorylation PhosphoSitePlus
K82 Sumoylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
T88 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 18039968
T88 Phosphorylation P36896 (ACVR1B) neXtProt   PhosphoSitePlus   Signor 18039968
T92 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 18039968
T92 Phosphorylation P36896 (ACVR1B) neXtProt   PhosphoSitePlus   Signor 18039968
S95 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y139 Phosphorylation PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
Y158 Phosphorylation PhosphoSitePlus
Y160 Phosphorylation PhosphoSitePlus
K192 Sumoylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K203 Sumoylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
C356 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K24 R24 Biomuta DOID:2531 / hematologic cancer [ cosmic ]