iPTMnet Report for O95475 (SIX6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95475 / SIX6_HUMAN
Protein Name Homeobox protein SIX6
Gene Name Name: SIX6
Synonyms:OPTX2,SIX9;
Organism Homo sapiens (Human)

PRO ID PR:O95475
DAG View
PRO Name homeobox protein SIX6 (human)
Definition A homeobox protein SIX6 that is encoded in the genome of human.
Short Label hSIX6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95475 (SIX6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
Y152 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
T212 Phosphorylation PhosphoSitePlus   UniProt 19690332
T220 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus   UniProt 19690332
S225 Phosphorylation PhosphoSitePlus   UniProt 19690332
S227 Phosphorylation PhosphoSitePlus   UniProt 19690332
S228 Phosphorylation PhosphoSitePlus   UniProt 19690332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y96 C96 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y96 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K131 R131 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y147 N147 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y152 C152 Biomuta DOID:363 / uterine cancer [ cosmic ]
S156 R156 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T212 A212 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S221 I221 Biomuta DOID:4606 / bile duct cancer [ cosmic ]