iPTMnet Report for O95470 (SGPL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95470 / SGPL1_HUMAN
Protein Name Sphingosine-1-phosphate lyase 1
Gene Name Name: SGPL1
Synonyms:KIAA1252;
Organism Homo sapiens (Human)

PRO ID PR:O95470
DAG View
PRO Name sphingosine-1-phosphate lyase 1 (human)
Definition A sphingosine-1-phosphate lyase 1 that is encoded in the genome of human.
Short Label hSGPL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95470 (SGPL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K25 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
K247 Methylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K353 Acetylation PhosphoSitePlus   UniProt 19608861
K353 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
T468 Phosphorylation HPRD   PhosphoSitePlus 18691976
S507 Phosphorylation PhosphoSitePlus
T509 Phosphorylation PhosphoSitePlus
T552 Phosphorylation HPRD 18691976
S559 Phosphorylation HPRD 18691976, 20068231
S564 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19690332, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S118 Y118 Biomuta DOID:4362 / cervical cancer [ cosmic ]
T552 I552 Biomuta [ cosmic ]