Protein Information

Cytoscape View

UniProt AC / UniProt ID O95433 / AHSA1_HUMAN
Protein Name Activator of 90 kDa heat shock protein ATPase homolog 1
Gene Name Name: AHSA1
Organism Homo sapiens (Human)

PRO ID PR:O95433
DAG View
PRO Name activator of 90 kDa heat shock protein ATPase homolog 1 (human)
Definition An activator of 90 kDa heat shock protein ATPase homolog 1 that is encoded in the genome of human.
Short Label hAHSA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O95433 (AHSA1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K3 Acetylation PhosphoSitePlus   UniProt 19608861
K3 Methylation PhosphoSitePlus
K3 Ubiquitination PhosphoSitePlus
R30 Methylation PhosphoSitePlus
K39 Acetylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
Y151 Phosphorylation PhosphoSitePlus
K182 Sumoylation PhosphoSitePlus
T183 Phosphorylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
K194 Ubiquitination PhosphoSitePlus
K203 Acetylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
C207 S-Nitrosylation dbSNO 19483679
K208 Ubiquitination PhosphoSitePlus
K212 Acetylation PhosphoSitePlus   UniProt 19608861
K212 Ubiquitination PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
Y223 Phosphorylation P00519 (ABL1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 29127155, 26693507, 26235616
T241 Phosphorylation PhosphoSitePlus
K249 Acetylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus   UniProt 23186163
K268 Ubiquitination PhosphoSitePlus
R305 Methylation PhosphoSitePlus
R321 Methylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
Y333 Phosphorylation PhosphoSitePlus
R336 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S109 Phosphorylation HPRD 20068231
S120 Phosphorylation HPRD 20068231
S122 Phosphorylation HPRD 20068231
T154 Phosphorylation HPRD 20068231
S193 Phosphorylation HPRD 20068231
T214 Phosphorylation HPRD 20068231
T217 Phosphorylation HPRD 20068231
S218 Phosphorylation HPRD 20068231
Y223 Phosphorylation HPRD 20068231
S258 Phosphorylation HPRD 20068231

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O95433 (AHSA1) Y223 P07900 (HSP90AA1) increased_association eFIP 29127155
Phosphorylation P07900 (HSP90AA1) Y313 O95433 (AHSA1) decreased_association eFIP 31189925

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R30 K30 Biomuta DOID:4362 / cervical cancer [ tcga ]
K94 R94 Biomuta DOID:1324 / lung cancer [ cosmic ]
S109 F109 Biomuta DOID:1324 / lung cancer [ tcga ]
K137 N137 Biomuta DOID:363 / uterine cancer [ tcga ]
R321 Q321 Biomuta DOID:1909 / melanoma [ cosmic ]
Y333 C333 Biomuta DOID:4362 / cervical cancer [ tcga ]
R336 H336 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic ]
R336 C336 Biomuta DOID:1612 / breast cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]