Protein Information

Cytoscape View


UniProt AC / UniProt ID O95425 / SVIL_HUMAN
Protein Name Supervillin
Gene Name Name: SVIL
Organism Homo sapiens (Human)

PRO ID PR:O95425
DAG View
PRO Name supervillin (human)
Definition A supervillin that is encoded in the genome of human.
Short Label hSVIL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95425 (SVIL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S50 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S56 Phosphorylation PhosphoSitePlus
T62 Phosphorylation PhosphoSitePlus
S63 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S65 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S66 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S86 Phosphorylation PhosphoSitePlus
Y88 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
Y120 Phosphorylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
Y167 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
S221 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...20068231
S226 Phosphorylation phospho.ELM 17081983
S231 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
S238 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 23750008
T240 Phosphorylation PhosphoSitePlus   UniProt 24275569
S245 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231
S253 Phosphorylation PhosphoSitePlus   UniProt 24275569
S259 Phosphorylation PhosphoSitePlus
S261 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S263 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S270 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 17081983, 18669648, ...24275569, 20068231
S319 Phosphorylation PhosphoSitePlus
Y339 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
T545 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
T552 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
T628 Phosphorylation PhosphoSitePlus
Y642 Phosphorylation PhosphoSitePlus
S644 Phosphorylation PhosphoSitePlus
T657 Phosphorylation PhosphoSitePlus
T672 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
S675 Phosphorylation PhosphoSitePlus
T677 Phosphorylation PhosphoSitePlus
T679 Phosphorylation PhosphoSitePlus
S707 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
T736 Phosphorylation phospho.ELM 17525332
S769 Phosphorylation PhosphoSitePlus   UniProt 24275569
K818 Ubiquitination PhosphoSitePlus
K824 Ubiquitination PhosphoSitePlus
Y850 Phosphorylation PhosphoSitePlus
T852 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 17525332, 23186163, ...18669648
T856 Phosphorylation PhosphoSitePlus
S872 Phosphorylation PhosphoSitePlus
T896 Phosphorylation PhosphoSitePlus
S905 Phosphorylation PhosphoSitePlus
Y909 Phosphorylation PhosphoSitePlus
S913 Phosphorylation PhosphoSitePlus
S914 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
S918 Phosphorylation PhosphoSitePlus
S920 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
S924 Phosphorylation PhosphoSitePlus   UniProt 20068231
K927 Methylation PhosphoSitePlus
S938 Phosphorylation PhosphoSitePlus
Y947 Phosphorylation PhosphoSitePlus
K953 Acetylation PhosphoSitePlus
S961 Phosphorylation PhosphoSitePlus
Y966 Phosphorylation PhosphoSitePlus
S968 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S975 Phosphorylation PhosphoSitePlus
Y976 Phosphorylation PhosphoSitePlus
K992 Acetylation PhosphoSitePlus
Y993 Phosphorylation PhosphoSitePlus
S1000 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1052 Phosphorylation PhosphoSitePlus
T1078 Phosphorylation PhosphoSitePlus
T1111 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1120 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S1122 Phosphorylation PhosphoSitePlus
S1126 Phosphorylation PhosphoSitePlus
S1137 Phosphorylation PhosphoSitePlus
S1168 Phosphorylation PhosphoSitePlus
T1175 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1177 Phosphorylation PhosphoSitePlus
K1188 Ubiquitination PhosphoSitePlus
R1203 Methylation PhosphoSitePlus   UniProt 24129315
R1217 Methylation PhosphoSitePlus
K1220 Ubiquitination PhosphoSitePlus
K1221 Ubiquitination PhosphoSitePlus
S1225 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
T1227 Phosphorylation PhosphoSitePlus
T1230 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1234 Phosphorylation PhosphoSitePlus
K1239 Ubiquitination PhosphoSitePlus
S1314 Phosphorylation PhosphoSitePlus
Y1317 Phosphorylation phospho.ELM 18669648
S1322 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
Y1378 Phosphorylation PhosphoSitePlus
S1405 Phosphorylation PhosphoSitePlus
S1422 Phosphorylation PhosphoSitePlus
S1425 Phosphorylation PhosphoSitePlus
S1497 Phosphorylation PhosphoSitePlus
T1501 Phosphorylation PhosphoSitePlus
T1505 Phosphorylation PhosphoSitePlus
Y1579 Phosphorylation PhosphoSitePlus
K1678 Ubiquitination PhosphoSitePlus
Y1710 Phosphorylation PhosphoSitePlus
S1717 Phosphorylation PhosphoSitePlus
S1790 Phosphorylation PhosphoSitePlus
T1791 Phosphorylation PhosphoSitePlus
S1795 Phosphorylation PhosphoSitePlus
S1904 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S50 Phosphorylation HPRD 18669648, 19691289, 20068231
S63 Phosphorylation HPRD 18669648
S65 Phosphorylation HPRD 18669648
S66 Phosphorylation HPRD 18669648
S86 Phosphorylation HPRD 20068231
S221 Phosphorylation HPRD 18669648, 18452278, 19691289, ...20068231, 17081983
T229 Phosphorylation HPRD 17081983
S237 Phosphorylation HPRD 17081983
S238 Phosphorylation HPRD 18669648, 17081983, 20068231, ...19691289
T240 Phosphorylation HPRD 17081983
S245 Phosphorylation HPRD 17322306, 18212344, 18767875, ...19691289, 18452278, 19651622, 18669648, 20166139, 20068231
S259 Phosphorylation HPRD 19691289, 20068231
S261 Phosphorylation HPRD 20068231
S263 Phosphorylation HPRD 17081983, 20068231
S270 Phosphorylation HPRD 18088087, 19664994, 20058876, ...19691289, 18452278, 20068231
S319 Phosphorylation HPRD 19691289
T657 Phosphorylation HPRD 18077418
S707 Phosphorylation HPRD 18669648, 18212344, 20068231, ...19691289
Y850 Phosphorylation HPRD 18452278
T852 Phosphorylation HPRD 18767875, 18669648, 15302935, ...19664994
S872 Phosphorylation HPRD 20068231
S914 Phosphorylation HPRD 20068231
S920 Phosphorylation HPRD 18691976, 19664994, 19007248, ...19691289, 18669648, 20068231
S924 Phosphorylation HPRD 20068231
S938 Phosphorylation HPRD 20068231
Y966 Phosphorylation HPRD 18452278
S968 Phosphorylation HPRD 20166139, 20068231, 18452278
T1111 Phosphorylation HPRD 18669648, 20068231
S1120 Phosphorylation HPRD 18669648, 19664995, 20068231, ...19691289
T1175 Phosphorylation HPRD 17081983
Y1317 Phosphorylation HPRD 18669648
S1322 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
T1828 Phosphorylation HPRD 20068231
S1904 Phosphorylation HPRD 18212344
T1910 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S50 Phosphorylation HPRD   phospho.ELM 18669648, 19691289, 20068231
S63 Phosphorylation HPRD   phospho.ELM 18669648
S65 Phosphorylation HPRD   phospho.ELM 18669648
S66 Phosphorylation HPRD   phospho.ELM 18669648
S86 Phosphorylation HPRD 20068231
S221 Phosphorylation HPRD   phospho.ELM 18669648, 18452278, 19691289, ...20068231, 17081983
T229 Phosphorylation HPRD 17081983
S237 Phosphorylation HPRD 17081983
S238 Phosphorylation HPRD   phospho.ELM 18669648, 17081983, 20068231, ...19691289
T240 Phosphorylation HPRD 17081983
S245 Phosphorylation HPRD   phospho.ELM 17322306, 18212344, 18767875, ...19691289, 18452278, 19651622, 18669648, 20166139, 20068231
S251 Phosphorylation HPRD 17081983
S253 Phosphorylation HPRD 17081983
S259 Phosphorylation HPRD 17081983, 20068231, 19691289
S261 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 20068231
S263 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 20068231, ...18220336
S270 Phosphorylation HPRD   PhosphoSitePlus 18088087, 17081983, 19664994, ...20058876, 19691289, 18452278, 18669648, 20068231
T278 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
T283 Phosphorylation PhosphoSitePlus
S313 Phosphorylation HPRD 18669648, 18212344, 20068231, ...19691289
S340 Phosphorylation PhosphoSitePlus
T342 Phosphorylation HPRD   PhosphoSitePlus 17525332
Y424 Phosphorylation HPRD   PhosphoSitePlus 18452278
T426 Phosphorylation HPRD   PhosphoSitePlus 11707406, 18669648, 19664994, ...18767875
S446 Phosphorylation HPRD 20068231
S488 Phosphorylation HPRD 20068231
S494 Phosphorylation HPRD 18691976, 19664994, 19007248, ...19691289, 18669648, 20068231
S498 Phosphorylation HPRD 20068231
S512 Phosphorylation HPRD 20068231
Y540 Phosphorylation HPRD 18452278
S542 Phosphorylation HPRD 20166139, 20068231, 18452278
S626 Phosphorylation PhosphoSitePlus
T685 Phosphorylation HPRD 18669648, 20068231
S694 Phosphorylation HPRD 18669648, 19664995, 20068231, ...19691289
T749 Phosphorylation HPRD 17081983
S799 Phosphorylation PhosphoSitePlus
T804 Phosphorylation PhosphoSitePlus
Y891 Phosphorylation HPRD 18669648
S896 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
T1402 Phosphorylation HPRD 20068231
S1478 Phosphorylation HPRD 18212344
T1484 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S261 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S86 L86 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S212 G212 Biomuta DOID:363 / uterine cancer [ tcga ]
S226 I226 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S237 F237 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y642 C642 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S644 F644 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S673 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S675 L675 Biomuta DOID:1324 / lung cancer [ tcga ] DOID:263 / kidney cancer [ cosmic ]
T677 R677 Biomuta DOID:1324 / lung cancer [ tcga ]
T677 M677 Biomuta DOID:5041 / esophageal cancer [ icgc ]
T736 P736 Biomuta DOID:1612 / breast cancer [ icgc ]
K818 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T856 A856 Biomuta DOID:363 / uterine cancer [ tcga ]
T856 K856 Biomuta DOID:1324 / lung cancer [ tcga ]
T896 I896 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y909 F909 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S918 L918 Biomuta DOID:363 / uterine cancer [ icgc, tcga ] DOID:1612 / breast cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S920 C920 Biomuta DOID:1324 / lung cancer [ tcga ]
S938 I938 Biomuta DOID:1324 / lung cancer [ cosmic ]
S975 Y975 Biomuta DOID:3571 / liver cancer [ icgc ]
Y976 N976 Biomuta DOID:2531 / hematologic cancer [ icgc ]
Y976 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T1111 M1111 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S1120 L1120 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S1122 R1122 Biomuta DOID:3571 / liver cancer [ icgc ]
S1126 Y1126 Biomuta DOID:363 / uterine cancer [ tcga ]
S1314 T1314 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1314 G1314 Biomuta DOID:1909 / melanoma [ cosmic ]
S1497 L1497 Biomuta DOID:1324 / lung cancer [ tcga ]
S1790 N1790 Biomuta DOID:3571 / liver cancer [ tcga ]
T1791 M1791 Biomuta DOID:1909 / melanoma [ icgc, tcga ]