iPTMnet Report for O95402 (MED26)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95402 / MED26_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 26
Gene Name Name: MED26
Synonyms:ARC70,CRSP7;
Organism Homo sapiens (Human)

PRO ID PR:O95402
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 26 (human)
Definition A mediator of RNA polymerase II transcription subunit 26 that is encoded in the genome of human.
Short Label hMED26
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95402 (MED26) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K71 Acetylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
T310 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus
S337 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S361 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S373 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
T431 Phosphorylation PhosphoSitePlus
S447 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 35561310
S455 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus   UniProt 23186163
S491 Phosphorylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
T310 Phosphorylation HPRD 20068231
S314 Phosphorylation HPRD 20068231
S322 Phosphorylation HPRD 20068231
T323 Phosphorylation HPRD 20068231
S337 Phosphorylation HPRD 17081983
S361 Phosphorylation HPRD 18669648, 20068231
S447 Phosphorylation HPRD 17081983, 18452278
S535 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S274 I274 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S377 C377 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S386 L386 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T431 M431 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S494 G494 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S495 N495 Biomuta DOID:1324 / lung cancer [ cosmic ]