Protein Information

Cytoscape View


UniProt AC / UniProt ID O95382 / M3K6_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase 6
Gene Name Name: MAP3K6
Synonyms:ASK2,MAPKKK6,MEKK6;
Organism Homo sapiens (Human)

PRO ID PR:O95382
DAG View
PRO Name mitogen-activated protein kinase kinase kinase 6 (human)
Definition A mitogen-activated protein kinase kinase kinase 6 that is encoded in the genome of human.
Short Label hMAP3K6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95382 (MAP3K6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S251 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
Y717 Phosphorylation PhosphoSitePlus
K773 Ubiquitination PhosphoSitePlus
K795 Ubiquitination PhosphoSitePlus
T801 Phosphorylation PhosphoSitePlus
T806 Phosphorylation O95382 (MAP3K6) PhosphoSitePlus 17210579
S896 Phosphorylation PhosphoSitePlus
T899 Phosphorylation PhosphoSitePlus
K910 Ubiquitination PhosphoSitePlus
S912 Phosphorylation PhosphoSitePlus
S917 Phosphorylation PhosphoSitePlus
S964 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 19935702, 23186163
S984 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163, ...19369195
K999 Ubiquitination PhosphoSitePlus
S1129 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
S1149 Phosphorylation PhosphoSitePlus   UniProt 19369195
S1281 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T806 Phosphorylation O95382 (MAP3K6) HPRD 17210579
S912 Phosphorylation HPRD 18691976
S914 Phosphorylation HPRD 18691976
S964 Phosphorylation HPRD 18691976
S984 Phosphorylation HPRD 18691976, 18669648
S1129 Phosphorylation HPRD 18691976


O95382 (MAP3K6) as PTM Enzyme



Substrate Site Score Source PMID
O95382-1 (MAP3K6) T806 HPRD   PhosphoSitePlus 17210579
P45983 (MAPK8) T183 PhosphoSitePlus 17210579
P45983 (MAPK8) Y185 PhosphoSitePlus 17210579
Q16539 (MAPK14) T180 PhosphoSitePlus 17210579
Q16539 (MAPK14) Y182 PhosphoSitePlus 17210579
Q99683 (MAP3K5) T838 neXtProt 17210579


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S251 N251 Biomuta DOID:363 / uterine cancer [ tcga ]
S912 N912 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S1129 * Biomuta DOID:3571 / liver cancer [ icgc ]
S1149 R1149 Biomuta DOID:1909 / melanoma [ cosmic ]