iPTMnet Report for O95382 (MAP3K6)
Protein Information
UniProt AC / UniProt ID | O95382 / M3K6_HUMAN |
Protein Name | Mitogen-activated protein kinase kinase kinase 6 |
Gene Name | Name: MAP3K6 Synonyms:ASK2,MAPKKK6,MEKK6; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O95382 |
PRO Name | mitogen-activated protein kinase kinase kinase 6 (human) |
Definition | A mitogen-activated protein kinase kinase kinase 6 that is encoded in the genome of human. |
Short Label | hMAP3K6 |
Category | organism-gene |
O95382 (MAP3K6) as Substrate
Site | PTM Type | PTM Enzyme |
Score
| Source | PMID | |
---|---|---|---|---|---|---|
S251 | Phosphorylation | score1 | PhosphoSitePlus | |||
S367 | Phosphorylation | score1 | PhosphoSitePlus | |||
K540 | Ubiquitination | score1 | PhosphoSitePlus | |||
K677 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y717 | Phosphorylation | score1 | PhosphoSitePlus | |||
K773 | Ubiquitination | score1 | PhosphoSitePlus | |||
K795 | Ubiquitination | score1 | PhosphoSitePlus | |||
T801 | Phosphorylation | score1 | PhosphoSitePlus | |||
T806 | Phosphorylation | O95382 (MAP3K6) | score3 | PhosphoSitePlus Signor | 17210579 | |
S896 | Phosphorylation | score1 | PhosphoSitePlus | |||
T899 | Phosphorylation | score1 | PhosphoSitePlus | |||
K910 | Ubiquitination | score1 | PhosphoSitePlus | |||
S912 | Phosphorylation | score1 | PhosphoSitePlus | |||
S917 | Phosphorylation | score1 | PhosphoSitePlus | |||
S964 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 19935702, 23186163 | ||
S984 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 18669648, 23186163, ...19369195 | ||
K999 | Ubiquitination | score1 | PhosphoSitePlus | |||
S1129 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 23186163, 19369195 | ||
S1149 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
S1281 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1286 | O-Glycosylation | score1 | GlyGen | 22564745, 30059200, 30620550 |
Site | PTM Type | PTM Enzyme |
Score
| Source | PMID | |
---|---|---|---|---|---|---|
T806 | Phosphorylation | O95382 (MAP3K6) | score1 | HPRD | 17210579 | |
S912 | Phosphorylation | score0 | HPRD | 18691976 | ||
S914 | Phosphorylation | score0 | HPRD | 18691976 | ||
S964 | Phosphorylation | score0 | HPRD | 18691976 | ||
S984 | Phosphorylation | score0 | HPRD | 18691976, 18669648 | ||
S1129 | Phosphorylation | score0 | HPRD | 18691976 |
O95382 (MAP3K6) as PTM Enzyme
Substrate | Site | Score | Source | PMID | |
---|---|---|---|---|---|
O95382 (MAP3K6) | T806 | score3 | HPRD PhosphoSitePlus Signor | 17210579 | |
P45983 (MAPK8) | T183 | score2 | PhosphoSitePlus | 17210579 | |
P45983 (MAPK8) | Y185 | score2 | PhosphoSitePlus | 17210579 | |
Q16539 (MAPK14) | T180 | score2 | PhosphoSitePlus | 17210579 | |
Q16539 (MAPK14) | Y182 | score2 | PhosphoSitePlus | 17210579 | |
Q99683 (MAP3K5) | T838 | score3 | neXtProt Signor | 17210579 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S251 | N251 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S896 | N896 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K910 | E910 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
S914 | C914 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S1149 | R1149 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S1286 | Y1286 | Biomuta | DOID:363 / uterine cancer [ icgc ] |
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