iPTMnet Report for O95382 (MAP3K6)
Protein Information
| UniProt AC / UniProt ID | O95382 / M3K6_HUMAN |
| Protein Name | Mitogen-activated protein kinase kinase kinase 6 |
| Gene Name | Name: MAP3K6 Synonyms:ASK2,MAPKKK6,MEKK6; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O95382 |
| PRO Name | mitogen-activated protein kinase kinase kinase 6 (human) |
| Definition | A mitogen-activated protein kinase kinase kinase 6 that is encoded in the genome of human. |
| Short Label | hMAP3K6 |
| Category | organism-gene |
DAG ViewO95382 (MAP3K6) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S251 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S367 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K540 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K677 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y717 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K773 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K795 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T801 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T806 | Phosphorylation | O95382 (MAP3K6) | score3 | PhosphoSitePlus Signor | 17210579 | |
| S896 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T899 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K910 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S912 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S917 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S964 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 19935702, 23186163 | ||
| S984 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 18669648, 23186163, ... | ||
| K999 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S1129 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 23186163, 19369195 | ||
| S1149 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| S1281 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1286 | O-Glycosylation | score1 | GlyGen | 22564745, 30059200, 30620550 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T806 | Phosphorylation | O95382 (MAP3K6) | score1 | HPRD | 17210579 | |
| S912 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S914 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S964 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S984 | Phosphorylation | score0 | HPRD | 18691976, 18669648 | ||
| S1129 | Phosphorylation | score0 | HPRD | 18691976 |
O95382 (MAP3K6) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| O95382 (MAP3K6) | T806 | score3 | HPRD PhosphoSitePlus Signor | 17210579 | |
| P45983 (MAPK8) | T183 | score2 | PhosphoSitePlus | 17210579 | |
| P45983 (MAPK8) | Y185 | score2 | PhosphoSitePlus | 17210579 | |
| Q16539 (MAPK14) | T180 | score2 | PhosphoSitePlus | 17210579 | |
| Q16539 (MAPK14) | Y182 | score2 | PhosphoSitePlus | 17210579 | |
| Q99683 (MAP3K5) | T838 | score3 | neXtProt Signor | 17210579 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S251 | N251 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S896 | N896 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K910 | E910 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S914 | C914 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S1149 | R1149 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S1286 | Y1286 | Biomuta | DOID:363 / uterine cancer [ icgc ] |
 |