iPTMnet Report for O95376 (ARIH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95376 / ARI2_HUMAN
Protein Name E3 ubiquitin-protein ligase ARIH2
Gene Name Name: ARIH2
Synonyms:ARI2,TRIAD1;ORFNames:HT005;
Organism Homo sapiens (Human)

PRO ID PR:O95376
DAG View
PRO Name E3 ubiquitin-protein ligase ARIH2 (human)
Definition An E3 ubiquitin-protein ligase ARIH2 that is encoded in the genome of human.
Short Label hARIH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95376 (ARIH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K85 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
C270 Methylation IEDB 31844290
K279 Ubiquitination PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
Y337 Phosphorylation PhosphoSitePlus
Y338 Phosphorylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
S353 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
K364 Ubiquitination PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
Y428 Phosphorylation PhosphoSitePlus
Y432 Phosphorylation PhosphoSitePlus
Y433 Phosphorylation PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S113 F113 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K295 E295 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y432 F432 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]