iPTMnet Report for O95359 (TACC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95359 / TACC2_HUMAN
Protein Name Transforming acidic coiled-coil-containing protein 2
Gene Name Name: TACC2
Organism Homo sapiens (Human)

PRO ID PR:O95359
DAG View
PRO Name transforming acidic coiled-coil-containing protein 2 (human)
Definition A transforming acidic coiled-coil-containing protein 2 that is encoded in the genome of human.
Short Label hTACC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95359 (TACC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
T13 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
T18 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
S161 Phosphorylation phospho.ELM 18669648
Y164 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S197 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S201 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S245 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus   UniProt 20068231
V325 Phosphorylation UniProt 18669648
T411 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
S493 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S561 Phosphorylation PhosphoSitePlus   UniProt 20068231
S569 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S571 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S575 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S712 Phosphorylation PhosphoSitePlus
S749 Phosphorylation PhosphoSitePlus
S758 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S859 Phosphorylation PhosphoSitePlus
S962 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T983 Phosphorylation PhosphoSitePlus
T986 Phosphorylation PhosphoSitePlus
S993 Phosphorylation PhosphoSitePlus
S1005 Phosphorylation PhosphoSitePlus
S1025 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T1235 Phosphorylation PhosphoSitePlus
Y1237 Phosphorylation PhosphoSitePlus
S1242 Phosphorylation PhosphoSitePlus
S1267 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1283 Phosphorylation PhosphoSitePlus
S1311 Phosphorylation phospho.ELM 18669648
S1313 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K1339 Methylation PhosphoSitePlus
K1346 Methylation PhosphoSitePlus
T1426 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1494 Phosphorylation IEDB 35494241
S1562 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T1566 Phosphorylation PhosphoSitePlus
S1608 Phosphorylation PhosphoSitePlus
S1635 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1761 Phosphorylation PhosphoSitePlus
S1768 Phosphorylation PhosphoSitePlus
S1796 Phosphorylation PhosphoSitePlus
S1946 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1947 Phosphorylation PhosphoSitePlus
S1949 Phosphorylation phospho.ELM 18669648
S2072 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 24275569
T2073 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2075 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2088 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2092 Phosphorylation phospho.ELM 18669648
S2122 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2134 Phosphorylation PhosphoSitePlus
T2147 Phosphorylation PhosphoSitePlus
C2203 S-Nitrosylation dbSNO 26338901
S2218 Phosphorylation PhosphoSitePlus
S2226 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
T2246 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S2248 Phosphorylation PhosphoSitePlus
S2250 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2256 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18669648, 20068231
S2262 Phosphorylation PhosphoSitePlus
S2270 Phosphorylation PhosphoSitePlus
T2307 Phosphorylation phospho.ELM 18669648
T2314 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2317 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231
S2321 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231, ...17081983
S2359 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T2373 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2377 Phosphorylation phospho.ELM 18669648
S2389 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S2390 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2392 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2394 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S2397 Phosphorylation PhosphoSitePlus
S2403 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T2428 Phosphorylation phospho.ELM 18669648
T2430 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2440 Phosphorylation PhosphoSitePlus
S2443 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2447 Phosphorylation PhosphoSitePlus
T2451 Phosphorylation PhosphoSitePlus   UniProt 20068231
T2455 Phosphorylation PhosphoSitePlus   UniProt 20068231
T2458 Phosphorylation PhosphoSitePlus   UniProt 20068231
T2469 Phosphorylation PhosphoSitePlus
S2512 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...20068231
Y2519 Phosphorylation PhosphoSitePlus
S2522 Phosphorylation PhosphoSitePlus
S2534 Phosphorylation PhosphoSitePlus   UniProt 23186163
K2543 Ubiquitination PhosphoSitePlus
Y2548 Phosphorylation PhosphoSitePlus
S2554 Phosphorylation PhosphoSitePlus
S2557 Phosphorylation PhosphoSitePlus   UniProt 20068231
S2561 Phosphorylation PhosphoSitePlus
S2562 Phosphorylation PhosphoSitePlus
S2567 Phosphorylation PhosphoSitePlus
S2569 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T2571 Phosphorylation phospho.ELM 18669648
C2573 S-Nitrosylation dbSNO 26338901
S2576 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2577 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T2625 Phosphorylation phospho.ELM   UniProt 18669648
Y2726 Phosphorylation PhosphoSitePlus
K2736 Acetylation PhosphoSitePlus
K2784 Ubiquitination PhosphoSitePlus
K2791 Ubiquitination PhosphoSitePlus
K2830 Ubiquitination PhosphoSitePlus
Y2839 Phosphorylation PhosphoSitePlus
K2884 Acetylation PhosphoSitePlus
K2927 Acetylation PhosphoSitePlus
K2929 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation HPRD 18669648, 20068231
S27 Phosphorylation HPRD 18669648
S150 Phosphorylation HPRD 18669648, 20068231
T151 Phosphorylation HPRD 18669648, 20068231
S153 Phosphorylation HPRD 18669648
S166 Phosphorylation HPRD 18669648
S170 Phosphorylation HPRD 18669648
S200 Phosphorylation HPRD 18669648
S304 Phosphorylation HPRD 17322306, 18669648, 19664995, ...20068231
T324 Phosphorylation HPRD 18669648, 20068231
S328 Phosphorylation HPRD 18669648
S334 Phosphorylation HPRD 18669648, 16964243, 20068231
T385 Phosphorylation HPRD 18669648
T392 Phosphorylation HPRD 18669648, 20068231
S395 Phosphorylation HPRD 17081983, 18767875, 19664994, ...19651622, 18669648, 20068231
S399 Phosphorylation HPRD 17081983, 18767875, 19664994, ...19651622, 18669648, 20068231
S437 Phosphorylation HPRD 18669648, 20068231
T451 Phosphorylation HPRD 18669648
S455 Phosphorylation HPRD 18669648
S467 Phosphorylation HPRD 18669648
S468 Phosphorylation HPRD 18669648
S470 Phosphorylation HPRD 18669648
S472 Phosphorylation HPRD 18669648
S481 Phosphorylation HPRD 18669648
T506 Phosphorylation HPRD 18669648
S521 Phosphorylation HPRD 18669648
S525 Phosphorylation HPRD 17081983
T529 Phosphorylation HPRD 20068231
T533 Phosphorylation HPRD 20068231
T536 Phosphorylation HPRD 20068231
S589 Phosphorylation HPRD 20068231
S590 Phosphorylation HPRD 18669648, 19664994, 16964243, ...20068231, 19415658
S632 Phosphorylation HPRD 20068231
S635 Phosphorylation HPRD 17322306, 20068231
S639 Phosphorylation HPRD 20068231
S640 Phosphorylation HPRD 20068231
S645 Phosphorylation HPRD 20068231
S647 Phosphorylation HPRD 18669648, 20068231
T649 Phosphorylation HPRD 18669648
S652 Phosphorylation HPRD 20068231
S654 Phosphorylation HPRD 18669648
S655 Phosphorylation HPRD 18669648
S780 Phosphorylation HPRD 20068231
S782 Phosphorylation HPRD 20068231
S797 Phosphorylation HPRD 20068231
S799 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T325 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T2625 Phosphorylation PhosphoSitePlus
S2642 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S41 Phosphorylation HPRD 20068231
S92 Phosphorylation HPRD 18669648, 20068231
S95 Phosphorylation HPRD 18669648
S218 Phosphorylation HPRD 18669648, 20068231
T219 Phosphorylation HPRD 18669648, 20068231
S221 Phosphorylation HPRD 18669648
S234 Phosphorylation HPRD 18669648
S238 Phosphorylation HPRD 18669648
S268 Phosphorylation HPRD 18669648
S372 Phosphorylation HPRD 17322306, 18669648, 19664995, ...20068231
T392 Phosphorylation HPRD 18669648, 20068231
S396 Phosphorylation HPRD 18669648
S402 Phosphorylation HPRD 18669648, 16964243, 20068231
T453 Phosphorylation HPRD 18669648
T460 Phosphorylation HPRD 18669648, 20068231
S463 Phosphorylation HPRD 17081983, 18767875, 19664994, ...19651622, 18669648, 20068231
S467 Phosphorylation HPRD 17081983, 18767875, 19664994, ...19651622, 18669648, 20068231
S505 Phosphorylation HPRD 18669648, 20068231
T519 Phosphorylation HPRD 18669648
S523 Phosphorylation HPRD 18669648
S535 Phosphorylation HPRD 18669648
S536 Phosphorylation HPRD 18669648
S538 Phosphorylation HPRD 18669648
S540 Phosphorylation HPRD 18669648
S549 Phosphorylation HPRD 18669648
T574 Phosphorylation HPRD 18669648
S589 Phosphorylation HPRD 18669648
S593 Phosphorylation HPRD 17081983
T597 Phosphorylation HPRD 20068231
T601 Phosphorylation HPRD 20068231
T604 Phosphorylation HPRD 20068231
S657 Phosphorylation HPRD 20068231
S658 Phosphorylation HPRD 18669648, 19664994, 16964243, ...20068231, 19415658
S700 Phosphorylation HPRD 20068231
S703 Phosphorylation HPRD 17322306, 20068231
S707 Phosphorylation HPRD 20068231
S708 Phosphorylation HPRD 20068231
S713 Phosphorylation HPRD 20068231
S715 Phosphorylation HPRD 18669648, 20068231
T717 Phosphorylation HPRD 18669648
S720 Phosphorylation HPRD 20068231
S722 Phosphorylation HPRD 18669648
S723 Phosphorylation HPRD 18669648
S848 Phosphorylation HPRD 20068231
S850 Phosphorylation HPRD 20068231
S865 Phosphorylation HPRD 20068231
S867 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation HPRD 18669648, 20068231
S27 Phosphorylation HPRD 18669648
S150 Phosphorylation HPRD 18669648, 20068231
T151 Phosphorylation HPRD 18669648, 20068231
S153 Phosphorylation HPRD 18669648
S166 Phosphorylation HPRD 18669648
S170 Phosphorylation HPRD 18669648
S200 Phosphorylation HPRD 18669648
S304 Phosphorylation HPRD 17322306, 18669648, 19664995, ...20068231
T324 Phosphorylation HPRD 18669648, 20068231
S328 Phosphorylation HPRD 18669648
S334 Phosphorylation HPRD 18669648, 16964243, 20068231
T385 Phosphorylation HPRD 18669648
T392 Phosphorylation HPRD 18669648, 20068231
S395 Phosphorylation HPRD 17081983, 18767875, 19664994, ...19651622, 18669648, 20068231
S399 Phosphorylation HPRD 17081983, 18767875, 19664994, ...19651622, 18669648, 20068231
S437 Phosphorylation HPRD 18669648, 20068231
T451 Phosphorylation HPRD 18669648
S455 Phosphorylation HPRD 18669648
S467 Phosphorylation HPRD 18669648
S468 Phosphorylation HPRD 18669648
S470 Phosphorylation HPRD 18669648
S472 Phosphorylation HPRD 18669648
S481 Phosphorylation HPRD 18669648
T506 Phosphorylation HPRD 18669648
S521 Phosphorylation HPRD 18669648
S525 Phosphorylation HPRD 17081983
T529 Phosphorylation HPRD 20068231
T533 Phosphorylation HPRD 20068231
T536 Phosphorylation HPRD 20068231
S589 Phosphorylation HPRD 20068231
S590 Phosphorylation HPRD 18669648, 19664994, 16964243, ...20068231, 19415658
S632 Phosphorylation HPRD 20068231
S635 Phosphorylation HPRD 17322306, 20068231
S639 Phosphorylation HPRD 20068231
S640 Phosphorylation HPRD 20068231
S645 Phosphorylation HPRD 20068231
S647 Phosphorylation HPRD 18669648, 20068231
T649 Phosphorylation HPRD 18669648
S652 Phosphorylation HPRD 20068231
S654 Phosphorylation HPRD 18669648
S655 Phosphorylation HPRD 18669648
S767 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S15 L15 Biomuta DOID:4159 / skin cancer [ cosmic ]
S153 F153 Biomuta DOID:4159 / skin cancer [ cosmic ]
S201 * Biomuta [ cosmic ]
S221 F221 Biomuta DOID:4159 / skin cancer [ cosmic ]
T324 A324 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T385 A385 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T392 A392 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S399 F399 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T451 I451 Biomuta DOID:1319 / brain cancer [ cosmic ]
T453 A453 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S455 F455 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S467 F467 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S468 L468 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T506 I506 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
T519 I519 Biomuta DOID:1319 / brain cancer [ cosmic ]
S523 F523 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S536 L536 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S561 N561 Biomuta DOID:184 / bone cancer [ cosmic ]
S571 L571 Biomuta DOID:4159 / skin cancer [ cosmic ]
T574 I574 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S590 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S639 P639 Biomuta DOID:1324 / lung cancer [ cosmic ]
S639 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S640 F640 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S655 R655 Biomuta DOID:4159 / skin cancer [ cosmic ]
S658 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S707 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S707 P707 Biomuta DOID:1324 / lung cancer [ cosmic ]
S708 F708 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S712 Y712 Biomuta DOID:363 / uterine cancer [ icgc ]
S712 F712 Biomuta DOID:4159 / skin cancer [ cosmic ]
S723 R723 Biomuta DOID:4159 / skin cancer [ cosmic ]
S780 F780 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S799 F799 Biomuta DOID:4159 / skin cancer [ cosmic ]
S848 F848 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S859 F859 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S867 F867 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic, cosmic, icgc, cosmic, icgc, cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc, cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S962 W962 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1025 F1025 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1283 F1283 Biomuta [ cosmic ]
S1796 T1796 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2075 F2075 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2134 F2134 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T2246 A2246 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S2248 A2248 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S2262 F2262 Biomuta DOID:4159 / skin cancer [ cosmic ]
T2307 A2307 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2321 F2321 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T2373 I2373 Biomuta DOID:1319 / brain cancer [ cosmic ]
S2377 F2377 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2390 L2390 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S2397 F2397 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T2428 I2428 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S2512 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S2522 F2522 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2534 F2534 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2561 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S2561 P2561 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2562 F2562 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S2577 R2577 Biomuta DOID:4159 / skin cancer [ cosmic ]