iPTMnet Report for O95352 (ATG7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95352 / ATG7_HUMAN
Protein Name Ubiquitin-like modifier-activating enzyme ATG7
Gene Name Name: ATG7
Synonyms:APG7L;
Organism Homo sapiens (Human)

PRO ID PR:O95352
DAG View
PRO Name ubiquitin-like modifier-activating enzyme ATG7 (human)
Definition A ubiquitin-like modifier-activating enzyme ATG7 that is encoded in the genome of human.
Short Label hATG7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95352 (ATG7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
T5 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
Y38 Phosphorylation PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K306 Acetylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
R420 Methylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
S531 Phosphorylation PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus   UniProt 24275569
Site PTM Type PTM Enzyme Score Source PMID
S698 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S618 Phosphorylation PhosphoSitePlus
T622 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
A2 V2 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
A2 S2 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T5 M5 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S11 F11 Biomuta DOID:4159 / skin cancer [ cosmic ]
K306 N306 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K306 M306 Biomuta DOID:3571 / liver cancer [ cosmic ]
R420 Q420 Biomuta DOID:363 / uterine cancer [ icgc ]
S490 R490 Biomuta DOID:1319 / brain cancer [ cosmic ]