iPTMnet Report for O95347 (SMC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95347 / SMC2_HUMAN
Protein Name Structural maintenance of chromosomes protein 2
Gene Name Name: SMC2
Synonyms:CAPE,SMC2L1;ORFNames:PRO0324;
Organism Homo sapiens (Human)

PRO ID PR:O95347
DAG View
PRO Name structural maintenance of chromosomes protein 2 (human)
Definition A structural maintenance of chromosomes protein 2 that is encoded in the genome of human.
Short Label hSMC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95347 (SMC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Ubiquitination PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
Y67 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K114 Acetylation PhosphoSitePlus   UniProt 19608861
K114 Ubiquitination PhosphoSitePlus
C132 Methylation IEDB 31844290
K152 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K222 Acetylation PhosphoSitePlus   UniProt 19608861
K222 Ubiquitination PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
T292 Phosphorylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K320 Acetylation PhosphoSitePlus
K321 Acetylation PhosphoSitePlus
K330 Acetylation PhosphoSitePlus
K336 Acetylation PhosphoSitePlus
K348 Acetylation PhosphoSitePlus
K353 Acetylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
T574 Phosphorylation PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
C585 S-Nitrosylation dbSNO 26338901
S669 Phosphorylation PhosphoSitePlus
K677 Acetylation PhosphoSitePlus   UniProt 19608861
K677 Ubiquitination PhosphoSitePlus
K682 Ubiquitination PhosphoSitePlus
K691 Ubiquitination PhosphoSitePlus
K706 Ubiquitination PhosphoSitePlus
K711 Ubiquitination PhosphoSitePlus
K732 Ubiquitination PhosphoSitePlus
T751 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30397120, 30379171, 34725712, 30620550, 34019948, 35289036, 33465208
S755 O-Glycosylation GlyGen 33465208
T762 O-Glycosylation GlyGen 33465208
K768 Acetylation PhosphoSitePlus
K792 Acetylation PhosphoSitePlus
K797 Acetylation PhosphoSitePlus
K813 Acetylation PhosphoSitePlus
K837 Acetylation PhosphoSitePlus
S906 Phosphorylation PhosphoSitePlus
K911 Ubiquitination PhosphoSitePlus
K936 Ubiquitination PhosphoSitePlus
K958 Acetylation PhosphoSitePlus
K958 Ubiquitination PhosphoSitePlus
K963 Acetylation PhosphoSitePlus
K971 Acetylation PhosphoSitePlus
K971 Ubiquitination PhosphoSitePlus
T992 Phosphorylation PhosphoSitePlus
K1003 Ubiquitination PhosphoSitePlus
K1014 Ubiquitination PhosphoSitePlus
T1017 Phosphorylation PhosphoSitePlus
T1018 Phosphorylation PhosphoSitePlus
K1025 Ubiquitination PhosphoSitePlus
K1026 Ubiquitination PhosphoSitePlus
K1036 Ubiquitination PhosphoSitePlus
K1039 Ubiquitination PhosphoSitePlus
K1079 Ubiquitination PhosphoSitePlus
K1158 Acetylation PhosphoSitePlus   UniProt 19608861
K1158 Methylation PhosphoSitePlus
K1158 Ubiquitination PhosphoSitePlus
T1159 Phosphorylation PhosphoSitePlus
K1160 Acetylation PhosphoSitePlus   UniProt 19608861
K1160 Methylation PhosphoSitePlus
K1160 Ubiquitination PhosphoSitePlus
T1172 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30397120, 30379171, 34725712, 30620550, 34019948, 35289036, 33465208
K1178 Ubiquitination PhosphoSitePlus
K1188 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S60 Phosphorylation HPRD 19691289
T171 Phosphorylation HPRD 20068231
T1017 Phosphorylation HPRD 20068231
T1018 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S268 F268 Biomuta DOID:4159 / skin cancer [ cosmic ]
K290 N290 Biomuta DOID:1324 / lung cancer [ cosmic ]
S477 N477 Biomuta DOID:363 / uterine cancer [ icgc ]
K481 N481 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K493 R493 Biomuta DOID:4159 / skin cancer [ cosmic ]
K515 N515 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S755 N755 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K797 E797 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K837 R837 Biomuta DOID:1324 / lung cancer [ cosmic ]
S906 Y906 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S906 F906 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1003 E1003 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T1018 A1018 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K1036 N1036 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1036 R1036 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K1079 N1079 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1159 I1159 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1160 * Biomuta DOID:4159 / skin cancer [ cosmic ]