iPTMnet Report for O95340 (PAPSS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95340 / PAPS2_HUMAN
Protein Name Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Gene Name Name: PAPSS2
Synonyms:ATPSK2;
Organism Homo sapiens (Human)

PRO ID PR:O95340
DAG View
PRO Name bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (human)
Definition A bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 that is encoded in the genome of human.
Short Label hPAPSS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95340 (PAPSS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation PhosphoSitePlus
Y20 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
R37 Methylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
T349 Phosphorylation PhosphoSitePlus
T351 Phosphorylation PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
Y508 Phosphorylation PhosphoSitePlus
T522 Phosphorylation PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
T579 Phosphorylation PhosphoSitePlus
K599 Ubiquitination PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T9 M9 Biomuta DOID:363 / uterine cancer [ icgc, icgc ]
T351 K351 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K534 M534 Biomuta DOID:4159 / skin cancer [ cosmic ]
T579 I579 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K602 T602 Biomuta DOID:10534 / stomach cancer [ cosmic ]