iPTMnet Report for O95297 (MPZL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95297 / MPZL1_HUMAN
Protein Name Myelin protein zero-like protein 1 precursor
Gene Name Name: MPZL1
Synonyms:PZR;ORFNames:UNQ849/PRO1787;
Organism Homo sapiens (Human)

PRO ID PR:O95297
DAG View
PRO Name myelin protein zero-like protein 1 (human)
Definition A myelin protein zero-like protein 1 that is encoded in the genome of human.
Short Label hMPZL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95297 (MPZL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
N50 N-Glycosylation GlyGen   UniProt 29741879, 19349973, 30392906, ...24190977
K55 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
N121 N-Glycosylation GlyGen 24190977
N124 N-Glycosylation GlyGen 24190977
N130 N-Glycosylation GlyGen   UniProt 29741879, 30392906, 24190977
N139 N-Glycosylation GlyGen 24190977
R151 Methylation PhosphoSitePlus
Y200 Phosphorylation phospho.ELM   PhosphoSitePlus 9792637
T201 Phosphorylation PhosphoSitePlus
C203 S-Nitrosylation dbSNO 26338901
S204 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T205 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S206 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S208 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S210 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
K213 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
S219 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...20068231
S221 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
T223 Phosphorylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
Y241 Phosphorylation P12931 (SRC) IntAct   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18083107, 11751924, 19690332, ...10681522
S247 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
S258 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S260 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y263 Phosphorylation P12931 (SRC) IntAct   phospho.ELM   PhosphoSitePlus   Signor   UniProt 23186163, 10681522, 18083107, ...18669648, 11751924, 19690332, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 20068231
S204 Phosphorylation HPRD 18669648, 20068231
T205 Phosphorylation HPRD 18578522, 18669648
S206 Phosphorylation HPRD 18669648, 17081983, 20068231
S208 Phosphorylation HPRD 18669648, 17081983, 20068231
S210 Phosphorylation HPRD 18691976, 18767875, 19664994, ...17322306, 18669648, 20068231
S219 Phosphorylation HPRD 18691976, 18578522, 19651622, ...18669648, 20068231, 17924679
S221 Phosphorylation HPRD 19413330, 18578522, 19651622, ...18669648, 20166139, 20068231
T223 Phosphorylation HPRD 17081983
Y241 Phosphorylation P12931 (SRC) HPRD 11751924, 20068231, 10681522
S258 Phosphorylation HPRD 18578522, 18669648
S260 Phosphorylation HPRD 18578522, 18669648
Y263 Phosphorylation P12931 (SRC) HPRD 17016520, 18578522, 10681522, ...19664994, 18669648, 18707149, 11751924, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 20068231
Y200 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
Y206 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N50 T50 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y200 F200 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S204 G204 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S209 R209 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K213 T213 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S219 P219 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S221 F221 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S258 L258 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S260 Y260 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y263 C263 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]