iPTMnet Report for O95292 (VAPB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95292 / VAPB_HUMAN
Protein Name Vesicle-associated membrane protein-associated protein B/C
Gene Name Name: VAPB
ORFNames:UNQ484/PRO983;
Organism Homo sapiens (Human)

PRO ID PR:O95292
DAG View
PRO Name vesicle-associated membrane protein-associated protein B/C (human)
Definition A vesicle-associated membrane protein-associated protein B/C that is encoded in the genome of human.
Short Label hVAPB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95292 (VAPB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 25944712
K3 Acetylation PhosphoSitePlus
K3 Ubiquitination PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
T27 Phosphorylation PhosphoSitePlus
T28 Phosphorylation PhosphoSitePlus
R38 Methylation PhosphoSitePlus
K43 Methylation PhosphoSitePlus
K45 Acetylation PhosphoSitePlus
K118 Acetylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
S142 O-Glycosylation GlyGen 23301498, 32574038, 34229054, ...33465208, 35083852, 32119511, 35289036, 28657654
S142 Phosphorylation PhosphoSitePlus
T143 O-Glycosylation GlyGen 23301498, 32574038, 34229054, ...33465208, 35083852, 32119511, 35289036, 28657654
T143 Phosphorylation PhosphoSitePlus
T144 O-Glycosylation GlyGen 33465208
S146 O-Glycosylation GlyGen 33465208
S146 Phosphorylation PhosphoSitePlus   UniProt 23186163
K147 Acetylation PhosphoSitePlus
K147 Sumoylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
T150 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S154 O-Glycosylation GlyGen 23301498, 32574038, 34229054, ...33465208, 35083852, 32119511, 35289036, 28657654
S154 Phosphorylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S158 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S159 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S160 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
T164 Phosphorylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
T201 O-Glycosylation GlyGen 23301498, 32574038, 34229054, ...33465208, 35083852, 32119511, 35289036, 28657654
T201 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
S206 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16565220
S209 O-Glycosylation GlyGen 33465208
S209 Phosphorylation PhosphoSitePlus
T214 O-Glycosylation GlyGen 33465208
T214 Phosphorylation PhosphoSitePlus
K216 Acetylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S146 Phosphorylation HPRD 18669648, 20068231
T150 Phosphorylation HPRD 18669648, 19007248, 20068231, ...19691289
S154 Phosphorylation HPRD 18669648
S156 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20166139, 20068231
S158 Phosphorylation HPRD 20166139, 18767875, 18578522, ...18669648, 18707149
S159 Phosphorylation HPRD 19651622, 20058876, 17081983
S160 Phosphorylation HPRD 19413330, 17081983, 19007248, ...19651622, 18669648, 20166139, 20068231
S204 Phosphorylation HPRD 18691976
S206 Phosphorylation HPRD 19413330, 16565220, 19691289, ...20068231, 19007248
S209 Phosphorylation HPRD 20068231
T214 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 R9 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R38 Q38 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K147 N147 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T150 A150 Biomuta DOID:363 / uterine cancer [ icgc ]
S156 F156 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S160 Y160 Biomuta DOID:363 / uterine cancer [ icgc ]
S160 F160 Biomuta DOID:4159 / skin cancer [ cosmic ]
T164 I164 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S204 N204 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K216 M216 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]