iPTMnet Report for O95279 (KCNK5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95279 / KCNK5_HUMAN
Protein Name Potassium channel subfamily K member 5
Gene Name Name: KCNK5
Synonyms:TASK2;
Organism Homo sapiens (Human)

PRO ID PR:O95279
DAG View
PRO Name potassium channel subfamily K member 5 (human)
Definition A potassium channel subfamily K member 5 that is encoded in the genome of human.
Short Label hKCNK5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95279 (KCNK5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K36 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
T283 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
Y347 Phosphorylation PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus
S371 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976
Y410 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K47 N47 Biomuta DOID:363 / uterine cancer [ icgc ]
S131 R131 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S266 Y266 Biomuta DOID:4159 / skin cancer [ cosmic ]
S282 N282 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T283 I283 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S285 P285 Biomuta DOID:1319 / brain cancer [ cosmic ]
S285 F285 Biomuta DOID:4159 / skin cancer [ cosmic ]
K296 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S438 L438 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]