Protein Information

Cytoscape View


UniProt AC / UniProt ID O95271 / TNKS1_HUMAN
Protein Name Poly [ADP-ribose] polymerase tankyrase-1
Gene Name Name: TNKS
Synonyms:PARP5A;
Organism Homo sapiens (Human)

PRO ID PR:O95271
DAG View
PRO Name poly [ADP-ribose] polymerase tankyrase-1 (human)
Definition A poly [ADP-ribose] polymerase tankyrase-1 that is encoded in the genome of human.
Short Label hTNKS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95271 (TNKS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T44 Phosphorylation PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
K335 Acetylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
Y379 Phosphorylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
T541 Phosphorylation PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
S640 Phosphorylation PhosphoSitePlus
K659 Ubiquitination PhosphoSitePlus
K667 Ubiquitination PhosphoSitePlus
H711 DIHYDROXYLATION IntAct 21251231
S726 Phosphorylation PhosphoSitePlus
Y727 Phosphorylation PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus
K760 Ubiquitination PhosphoSitePlus
K762 Ubiquitination PhosphoSitePlus
K767 Ubiquitination PhosphoSitePlus
K771 Ubiquitination PhosphoSitePlus
T777 Phosphorylation PhosphoSitePlus
K778 Acetylation PhosphoSitePlus
K779 Acetylation PhosphoSitePlus
K791 Ubiquitination PhosphoSitePlus
K812 Ubiquitination PhosphoSitePlus
K821 Ubiquitination PhosphoSitePlus
T839 Phosphorylation PhosphoSitePlus
K901 Ubiquitination PhosphoSitePlus
T916 Phosphorylation PhosphoSitePlus
T930 Phosphorylation PhosphoSitePlus
K932 Ubiquitination PhosphoSitePlus
S978 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P 17026964
T982 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P 17026964
S987 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P 17026964
S991 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P 17026964
K1020 Ubiquitination PhosphoSitePlus
K1081 Ubiquitination PhosphoSitePlus
T1128 Phosphorylation PhosphoSitePlus
K1152 Ubiquitination PhosphoSitePlus
K1167 Ubiquitination PhosphoSitePlus
K1195 Ubiquitination PhosphoSitePlus
K1238 Ubiquitination PhosphoSitePlus
K1258 Ubiquitination PhosphoSitePlus
Y1289 Phosphorylation PhosphoSitePlus
Y1292 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T49 A49 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, tcga ]
K791 R791 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T916 M916 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T916 S916 Biomuta DOID:1324 / lung cancer [ tcga ]
T1128 S1128 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K1238 N1238 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]