iPTMnet Report for O95267 (RASGRP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95267 / GRP1_HUMAN
Protein Name RAS guanyl-releasing protein 1
Gene Name Name: RASGRP1
Synonyms:RASGRP;
Organism Homo sapiens (Human)

PRO ID PR:O95267
DAG View
PRO Name RAS guanyl-releasing protein 1 (human)
Definition A RAS guanyl-releasing protein 1 that is encoded in the genome of human.
Short Label hRASGRP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95267 (RASGRP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T45 Phosphorylation PhosphoSitePlus
C69 Methylation IEDB 31844290
C80 Methylation IEDB 31844290
T91 Phosphorylation IEDB   PhosphoSitePlus 35494241
K160 Ubiquitination PhosphoSitePlus
T184 Phosphorylation Q04759 (PRKCQ) PhosphoSitePlus   RLIMS-P   UniProt 15899849, 28952923, 15657177
S198 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
C347 Methylation IEDB 31844290
K351 Ubiquitination PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
K620 Ubiquitination PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
S661 Phosphorylation PhosphoSitePlus
S694 Phosphorylation PhosphoSitePlus
K697 Ubiquitination PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
S715 Phosphorylation PhosphoSitePlus
K730 Ubiquitination PhosphoSitePlus
S732 Phosphorylation PhosphoSitePlus
K759 Ubiquitination PhosphoSitePlus
K766 Ubiquitination PhosphoSitePlus
K770 Ubiquitination PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
K783 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S198 F198 Biomuta DOID:4159 / skin cancer [ cosmic ]
K310 N310 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S314 L314 Biomuta [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K351 R351 Biomuta DOID:1324 / lung cancer [ cosmic ]
K511 R511 Biomuta DOID:363 / uterine cancer [ icgc ]
S661 A661 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S661 Y661 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S708 R708 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S711 Y711 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:3571 / liver cancer [ cosmic ]
S732 P732 Biomuta DOID:3571 / liver cancer [ cosmic ]
K766 T766 Biomuta DOID:3571 / liver cancer [ cosmic ]