Protein Information

Cytoscape View


UniProt AC / UniProt ID O95263 / PDE8B_HUMAN
Protein Name High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Gene Name Name: PDE8B
ORFNames:PIG22;
Organism Homo sapiens (Human)

PRO ID PR:O95263
DAG View
PRO Name high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (human)
Definition A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B that is encoded in the genome of human.
Short Label hPDE8B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95263 (PDE8B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T72 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
T362 Phosphorylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
S446 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K455 Ubiquitination PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
S517 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
Y521 Phosphorylation PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
K701 Ubiquitination PhosphoSitePlus
K738 Ubiquitination PhosphoSitePlus
K745 Ubiquitination PhosphoSitePlus
S754 Phosphorylation PhosphoSitePlus
K773 Ubiquitination PhosphoSitePlus
K811 Ubiquitination PhosphoSitePlus
K869 Ubiquitination PhosphoSitePlus
T870 Phosphorylation PhosphoSitePlus
K875 Ubiquitination PhosphoSitePlus
S878 Phosphorylation PhosphoSitePlus
S883 Phosphorylation PhosphoSitePlus
S885 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S78 Phosphorylation HPRD 15144186
S351 Phosphorylation HPRD 20068231
S517 Phosphorylation HPRD 18691976, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S420 Phosphorylation HPRD 18691976, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S351 Phosphorylation HPRD 20068231
T454 Phosphorylation PhosphoSitePlus
S462 Phosphorylation HPRD 18691976, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S331 Phosphorylation HPRD 20068231
S497 Phosphorylation HPRD 18691976, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S304 Phosphorylation HPRD 20068231
S470 Phosphorylation HPRD 18691976, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S79 N79 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K773 R773 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
S878 R878 Biomuta DOID:363 / uterine cancer [ tcga ]
S885 I885 Biomuta DOID:3571 / liver cancer [ icgc ]