iPTMnet Report for O95263 (PDE8B)
Protein Information
UniProt AC / UniProt ID | O95263 / PDE8B_HUMAN |
Protein Name | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
Gene Name | Name: PDE8B ORFNames:PIG22; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O95263 |
PRO Name | high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (human) |
Definition | A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B that is encoded in the genome of human. |
Short Label | hPDE8B |
Category | organism-gene |
O95263 (PDE8B) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T72 | Phosphorylation | score2 | IEDB PhosphoSitePlus | 35494241 | ||
S79 | Phosphorylation | score1 | PhosphoSitePlus | |||
T89 | Phosphorylation | score1 | PhosphoSitePlus | |||
S143 | Phosphorylation | score1 | PhosphoSitePlus | |||
K312 | Ubiquitination | score1 | PhosphoSitePlus | |||
K319 | Ubiquitination | score1 | PhosphoSitePlus | |||
K336 | Ubiquitination | score1 | PhosphoSitePlus | |||
K350 | Ubiquitination | score1 | PhosphoSitePlus | |||
S351 | Phosphorylation | score1 | PhosphoSitePlus | |||
S354 | Phosphorylation | score1 | PhosphoSitePlus | |||
K360 | Ubiquitination | score1 | PhosphoSitePlus | |||
T362 | Phosphorylation | score1 | PhosphoSitePlus | |||
K370 | Ubiquitination | score1 | PhosphoSitePlus | |||
K378 | Ubiquitination | score1 | PhosphoSitePlus | |||
K388 | Ubiquitination | score1 | PhosphoSitePlus | |||
K392 | Ubiquitination | score1 | PhosphoSitePlus | |||
S397 | Phosphorylation | score1 | PhosphoSitePlus | |||
K421 | Ubiquitination | score1 | PhosphoSitePlus | |||
S446 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
K455 | Ubiquitination | score1 | PhosphoSitePlus | |||
K495 | Ubiquitination | score1 | PhosphoSitePlus | |||
S517 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 20068231 | ||
Y521 | Phosphorylation | score1 | PhosphoSitePlus | |||
K637 | Ubiquitination | score1 | PhosphoSitePlus | |||
K701 | Ubiquitination | score1 | PhosphoSitePlus | |||
K738 | Ubiquitination | score1 | PhosphoSitePlus | |||
K745 | Ubiquitination | score1 | PhosphoSitePlus | |||
S754 | Phosphorylation | score1 | PhosphoSitePlus | |||
K773 | Ubiquitination | score1 | PhosphoSitePlus | |||
K811 | Ubiquitination | score1 | PhosphoSitePlus | |||
K869 | Ubiquitination | score1 | PhosphoSitePlus | |||
T870 | Phosphorylation | score1 | PhosphoSitePlus | |||
K875 | Ubiquitination | score1 | PhosphoSitePlus | |||
S878 | Phosphorylation | score1 | PhosphoSitePlus | |||
S883 | Phosphorylation | score1 | PhosphoSitePlus | |||
S885 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S78 | Phosphorylation | score0 | HPRD | 15144186 | ||
S351 | Phosphorylation | score0 | HPRD | 20068231 | ||
S517 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 20068231 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S420 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 20068231 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S351 | Phosphorylation | score0 | HPRD | 20068231 | ||
T454 | Phosphorylation | score1 | PhosphoSitePlus | |||
S462 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 20068231 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S79 | N79 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S354 | G354 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S420 | * | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
S462 | * | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
S470 | * | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
S497 | * | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
S517 | * | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
K637 | M637 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
K773 | R773 | Biomuta | DOID:184 / bone cancer [ cosmic ] | |
S878 | R878 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic ] |