iPTMnet Report for O95263 (PDE8B)
Protein Information
| UniProt AC / UniProt ID | O95263 / PDE8B_HUMAN |
| Protein Name | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
| Gene Name | Name: PDE8B ORFNames:PIG22; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O95263 |
| PRO Name | high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (human) |
| Definition | A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B that is encoded in the genome of human. |
| Short Label | hPDE8B |
| Category | organism-gene |
O95263 (PDE8B) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T72 | Phosphorylation | score2 | IEDB PhosphoSitePlus | 35494241 | ||
| S79 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T89 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S143 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K312 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K319 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K336 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K350 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S351 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S354 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K360 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T362 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K370 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K378 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K388 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K392 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S397 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K421 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S446 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| K455 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K495 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S517 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 20068231 | ||
| Y521 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K637 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K701 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K738 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K745 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S754 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K773 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K811 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K869 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T870 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K875 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S878 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S883 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S885 | Phosphorylation | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S78 | Phosphorylation | score0 | HPRD | 15144186 | ||
| S351 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S517 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 20068231 |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S420 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 20068231 |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S351 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T454 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S462 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 20068231 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S79 | N79 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S354 | G354 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S420 | * | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| S462 | * | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| S470 | * | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| S497 | * | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| S517 | * | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| K637 | M637 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| K773 | R773 | Biomuta | DOID:184 / bone cancer [ cosmic ] | |
| S878 | R878 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic ] |
DAG View