iPTMnet Report for O95251 (KAT7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95251 / KAT7_HUMAN
Protein Name Histone acetyltransferase KAT7
Gene Name Name: KAT7
Synonyms:HBO1;
Organism Homo sapiens (Human)

PRO ID PR:O95251
DAG View
PRO Name histone acetyltransferase KAT7 (human)
Definition A histone acetyltransferase KAT7 that is encoded in the genome of human.
Short Label hKAT7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95251 (KAT7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus   UniProt 23186163
T15 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S50 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 23186163, 18669648, ...28719581, 26572825
S52 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332, 18669648
S53 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 18669648, 26572825, ...28719581
S56 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332, 18669648
S57 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17525332, 23186163, 17081983, ...21406692, 18250300, 18669648, 19690332
S57 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 18250300
S64 Phosphorylation PhosphoSitePlus   UniProt 23186163
T67 Phosphorylation PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
T74 Phosphorylation PhosphoSitePlus
T78 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
T85 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18669648, 19690332, 18250300
T85 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 18250300
T88 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 23955388, 16964243, ...18250300, 18669648, 19690332
T88 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 18250300
T88 Phosphorylation P24941 (CDK2) PhosphoSitePlus 23955388
K90 Ubiquitination PhosphoSitePlus
T97 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S99 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S100 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S102 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...19690332
T104 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S111 Phosphorylation PhosphoSitePlus   UniProt 23186163
T115 Phosphorylation PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus   UniProt 21406692
T128 Phosphorylation PhosphoSitePlus
T130 Phosphorylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus   UniProt 24275569
K160 Acetylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S164 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S167 Phosphorylation PhosphoSitePlus
K171 Acetylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus   UniProt 23186163
K184 Sumoylation PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
K199 Acetylation PhosphoSitePlus   UniProt 19608861
S205 Phosphorylation PhosphoSitePlus
Y212 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
K221 Acetylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K229 Acetylation PhosphoSitePlus
K261 Acetylation PhosphoSitePlus
K269 Acetylation PhosphoSitePlus
K270 Acetylation PhosphoSitePlus
K277 Acetylation PhosphoSitePlus
T289 O-Glycosylation GlyGen 30379171
T293 O-Glycosylation GlyGen 30379171
K323 Acetylation PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
T331 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus   UniProt 23319590
T339 Phosphorylation PhosphoSitePlus
K376 Methylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
Y399 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
K432 Acetylation PhosphoSitePlus
C454 Methylation IEDB 31844290
S466 Phosphorylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
Y495 Phosphorylation PhosphoSitePlus
S506 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 20068231, 18220336
S512 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
K524 Ubiquitination PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
K576 Ubiquitination PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
K596 Acetylation PhosphoSitePlus
C602 Methylation IEDB 31844290
T606 Phosphorylation PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
T611 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD 17081983, 18452278
T15 Phosphorylation HPRD 17081983
S45 Phosphorylation HPRD 18077418
S50 Phosphorylation HPRD 18077418, 17525332, 18669648, ...19007248
S52 Phosphorylation HPRD 19413330, 18077418, 17525332, ...18669648
S53 Phosphorylation HPRD 19413330, 18077418, 17525332, ...18669648
S56 Phosphorylation HPRD 19413330, 17525332, 18669648, ...20068231, 19664995
S57 Phosphorylation HPRD 17525332, 18077418, 19007248, ...19664995, 19651622, 18669648, 20068231, 19691289
S64 Phosphorylation HPRD 17081983
T85 Phosphorylation HPRD 19413330, 18669648
T88 Phosphorylation HPRD 19413330, 16964243, 19664994, ...19664995, 18669648, 20068231
T97 Phosphorylation HPRD 18669648
S99 Phosphorylation HPRD 17081983, 19691289, 18452278, ...19651622, 18669648, 20068231
S100 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S102 Phosphorylation HPRD 19413330, 17081983, 19664995, ...18452278, 19651622, 18669648, 20068231
T104 Phosphorylation HPRD 18669648
S124 Phosphorylation HPRD 17081983, 20068231
T128 Phosphorylation HPRD 17081983, 20068231, 18452278
S158 Phosphorylation HPRD 17081983, 20068231
S162 Phosphorylation HPRD 20068231
S167 Phosphorylation HPRD 17081983
S178 Phosphorylation HPRD 20068231
S506 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S99 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
T104 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S216 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O95251 (KAT7) S50 Q92466 (DDB2) unknown eFIP 28719581


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S18 F18 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
S45 F45 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S50 I50 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S52 I52 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S56 F56 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S64 P64 Biomuta DOID:363 / uterine cancer [ icgc ]
S64 Y64 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T88 A88 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S135 Y135 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S158 F158 Biomuta DOID:4159 / skin cancer [ cosmic ]
K221 R221 Biomuta DOID:1324 / lung cancer [ cosmic ]
S403 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S466 L466 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S466 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S494 G494 Biomuta DOID:3571 / liver cancer [ cosmic ]
S506 F506 Biomuta DOID:1964 / fallopian tube cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S512 L512 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K576 E576 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]